Literature DB >> 14595000

Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS/MS: identification of ceramides containing sphingadienine.

Benoit Colsch1, Carlos Afonso, Iuliana Popa, Jacques Portoukalian, Françoise Fournier, Jean-Claude Tabet, Nicole Baumann.   

Abstract

Sphingoglycolipids (SGLs) are cell membrane constituents. As the ceramide structure influences the biological properties of the SGL, we characterized by electrospray ionization tandem mass spectrometry the molecular species of ceramides present in SGL of mouse brain. We report here for the first time the presence in mammalian brain of sphingadienine (d18:2). Sphingenine (d18:1) is present in all SGL species, in contrast to eicosasphingenine (d20:1), which is a constituent of only gangliosides. Sphingadienine is present in galactosylceramide and sulfatides. Free ceramides contain the three types of bases. Thus, there could be two separate pools of free ceramides (d18:1, d18:2 and d20:1, d18:1) as precursors of complex SGL.

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Year:  2003        PMID： 14595000     DOI： 10.1194/jlr.M300331-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  25 in total

1.  An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples.

Authors:  J H Suh; A M Makarova; J M Gomez; L A Paul; J D Saba
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2017-07-24       Impact factor: 3.205

Review 2.  Sphingolipidomics: methods for the comprehensive analysis of sphingolipids.

Authors:  Christopher A Haynes; Jeremy C Allegood; Hyejung Park; M Cameron Sullards
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-12-31       Impact factor: 3.205

3.  Structural characterization of neutral glycosphingolipids using high-performance liquid chromatography-electrospray ionization mass spectrometry with a repeated high-speed polarity and MSn switching system.

Authors:  Emi Ito; Hiroaki Waki; Kozo Miseki; Takashi Shimada; Taka-Aki Sato; Kazuaki Kakehi; Minoru Suzuki; Akemi Suzuki
Journal:  Glycoconj J       Date:  2013-12       Impact factor: 2.916

4.  Quantification of sulfatides and lysosulfatides in tissues and body fluids by liquid chromatography-tandem mass spectrometry.

Authors:  Mina Mirzaian; Gertjan Kramer; Ben J H M Poorthuis
Journal:  J Lipid Res       Date:  2015-01-27       Impact factor: 5.922

5.  Structural Analysis of Unsaturated Glycosphingolipids Using Shotgun Ozone-Induced Dissociation Mass Spectrometry.

Authors:  Rodell C Barrientos; Ngoc Vu; Qibin Zhang
Journal:  J Am Soc Mass Spectrom       Date:  2017-08-22       Impact factor: 3.109

6.  Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α-/- mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration.

Authors:  Michael A Kiebish; Dee M Young; John J Lehman; Xianlin Han
Journal:  J Lipid Res       Date:  2011-11-23       Impact factor: 5.922

7.  Flow injection tandem mass spectrometric measurement of ceramides of multiple chain lengths in biological samples.

Authors:  Jie Chen; Srinivas B Narayan; Aimee L Edinger; Michael J Bennett
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2011-11-18       Impact factor: 3.205

Review 8.  An introduction to sphingolipid metabolism and analysis by new technologies.

Authors:  Yanfeng Chen; Ying Liu; M Cameron Sullards; Alfred H Merrill
Journal:  Neuromolecular Med       Date:  2010-08-03       Impact factor: 3.843

9.  Global analysis of retina lipids by complementary precursor ion and neutral loss mode tandem mass spectrometry.

Authors:  Julia V Busik; Gavin E Reid; Todd A Lydic
Journal:  Methods Mol Biol       Date:  2009

10.  A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications.

Authors:  Xianlin Han; Xuntian Jiang
Journal:  Eur J Lipid Sci Technol       Date:  2009       Impact factor: 2.679
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