Literature DB >> 14594564

The Role of AMP-activated protein kinase in fuel selection by the stressed heart.

Raymond Russell1.   

Abstract

The heart responds to energetic stress with both acute and chronic changes in substrate metabolism. Recent work has demonstrated that the metabolic stress kinase AMP-activated protein kinase (AMPK) plays an important role in the acute regulation of carbohydrate and fatty acid metabolism in the setting of acute energetic stressors, such as ischemia/reperfusion, or increased workload, through covalent and noncovalent regulation of enzymes involved in intermediary metabolism. In addition, chronic activation of AMPK has been shown to affect the expression of key proteins regulating carbohydrate and fatty acid metabolism. Characterizing the effects of AMPK will provide important insights into its function in the normal heart and might provide new metabolic therapies for ischemic heart disease and heart failure.

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Year:  2003        PMID： 14594564     DOI： 10.1007/s11906-003-0053-6

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  48 in total

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Authors:  D G Hardie; D Carling
Journal:  Eur J Biochem       Date:  1997-06-01

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Authors:  Yasuo Ido; David Carling; Neil Ruderman
Journal:  Diabetes       Date:  2002-01       Impact factor: 9.461

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Authors:  S C Stein; A Woods; N A Jones; M D Davison; D Carling
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

4.  Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.

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Journal:  N Engl J Med       Date:  2001-06-14       Impact factor: 91.245

5.  The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

Authors:  Lee G D Fryer; Asha Parbu-Patel; David Carling
Journal:  J Biol Chem       Date:  2002-05-06       Impact factor: 5.157

6.  Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

Authors:  R Bergeron; S F Previs; G W Cline; P Perret; R R Russell; L H Young; G I Shulman
Journal:  Diabetes       Date:  2001-05       Impact factor: 9.461

7.  The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart.

Authors:  Markus Frederich; James A Balschi
Journal:  J Biol Chem       Date:  2001-11-13       Impact factor: 5.157

8.  Heart glucose transport and transporters in rat heart: regulation by insulin, workload and glucose.

Authors:  D Zaninetti; R Greco-Perotto; B Jeanrenaud
Journal:  Diabetologia       Date:  1988-02       Impact factor: 10.122

9.  Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo.

Authors:  R R Russell; R Yin; M J Caplan; X Hu; J Ren; G I Shulman; A J Sinusas; L H Young
Journal:  Circulation       Date:  1998-11-17       Impact factor: 29.690

10.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.

Authors:  T Yamauchi; J Kamon; Y Minokoshi; Y Ito; H Waki; S Uchida; S Yamashita; M Noda; S Kita; K Ueki; K Eto; Y Akanuma; P Froguel; F Foufelle; P Ferre; D Carling; S Kimura; R Nagai; B B Kahn; T Kadowaki
Journal:  Nat Med       Date:  2002-10-07       Impact factor: 53.440
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  3 in total

1.  Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.

Authors:  Rubin M Tuder; Laura A Davis; Brian B Graham
Journal:  Am J Respir Crit Care Med       Date:  2011-11-10       Impact factor: 21.405

2.  Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

Authors:  S L Longnus; C Ségalen; J Giudicelli; M P Sajan; R V Farese; E Van Obberghen
Journal:  Diabetologia       Date:  2005-11-11       Impact factor: 10.122

3.  AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K(+) channels.

Authors:  Andrey Sukhodub; Sofija Jovanović; Qingyou Du; Grant Budas; Allyson K Clelland; Mei Shen; Kei Sakamoto; Rong Tian; Aleksandar Jovanović
Journal:  J Cell Physiol       Date:  2007-01       Impact factor: 6.384
  3 in total

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