Literature DB >> 14594563

Transcriptional regulation of energy substrate metabolism in normal and hypertrophied heart.

Rong Tian1.   

Abstract

Impaired myocardial energy metabolism in cardiac hypertrophy and failure is characterized by decreased fatty-acid oxidation and increased glucose utilization. Mechanisms involving deactivation of peroxisome proliferator-activated receptor alpha/relinoid X receptor alpha (PPARalpha/RXRalpha),and activation of chicken ovalbumin upstream promoter transcription factor (COUP-TF), and transcription factors Sp1 and Sp3, lead to decreased capacity for fatty acid utilization in hypertrophied hearts. Furthermore, impaired myocardial energetic status stimulates glucose uptake and glycolysis, which, in combination with the permissive effect due to decreased fatty acid oxidation, promotes increases in glucose utilization in hypertrophied hearts. Finally, shifting substrate utilization toward glucose is likely adaptive and has the potential to delay transition to heart failure.

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Year:  2003        PMID： 14594563     DOI： 10.1007/s11906-003-0052-7

Source DB:  PubMed          Journal:  Curr Hypertens Rep        ISSN： 1522-6417            Impact factor:   5.369


  40 in total

1.  Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

Authors:  M C Sugden; M L Langdown; R A Harris; M J Holness
Journal:  Biochem J       Date:  2000-12-15       Impact factor: 3.857

2.  Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Authors:  T Hayashi; M F Hirshman; N Fujii; S A Habinowski; L A Witters; L J Goodyear
Journal:  Diabetes       Date:  2000-04       Impact factor: 9.461

3.  AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

Authors:  D G Hardie; I P Salt; S A Hawley; S P Davies
Journal:  Biochem J       Date:  1999-03-15       Impact factor: 3.857

Review 4.  Glucose for the heart.

Authors:  C Depre; J L Vanoverschelde; H Taegtmeyer
Journal:  Circulation       Date:  1999-02-02       Impact factor: 29.690

5.  The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

Authors:  Brian N Finck; John J Lehman; Teresa C Leone; Michael J Welch; Michael J Bennett; Attila Kovacs; Xianlin Han; Richard W Gross; Ray Kozak; Gary D Lopaschuk; Daniel P Kelly
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

6.  Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure.

Authors:  T R Wallhaus; M Taylor; T R DeGrado; D C Russell; P Stanko; R J Nickles; C K Stone
Journal:  Circulation       Date:  2001-05-22       Impact factor: 29.690

7.  Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice.

Authors:  Ronglih Liao; Mohit Jain; Lei Cui; Jessica D'Agostino; Francesco Aiello; Ivan Luptak; Soeun Ngoy; Richard M Mortensen; Rong Tian
Journal:  Circulation       Date:  2002-10-15       Impact factor: 29.690

8.  Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy.

Authors:  S Neubauer; M Horn; M Cramer; K Harre; J B Newell; W Peters; T Pabst; G Ertl; D Hahn; J S Ingwall; K Kochsiek
Journal:  Circulation       Date:  1997-10-07       Impact factor: 29.690

9.  Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium.

Authors:  J S Ingwall; D E Atkinson; K Clarke; J K Fetters
Journal:  Eur Heart J       Date:  1990-04       Impact factor: 29.983

10.  Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and alpha-subunit of electron transfer flavoprotein in rat.

Authors:  M Nagao; B Parimoo; K Tanaka
Journal:  J Biol Chem       Date:  1993-11-15       Impact factor: 5.157
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  18 in total

Review 1.  Mitochondrial energy metabolism in heart failure: a question of balance.

Authors:  Janice M Huss; Daniel P Kelly
Journal:  J Clin Invest       Date:  2005-03       Impact factor: 14.808

2.  Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Authors:  Jie Yan; Martin E Young; Lei Cui; Gary D Lopaschuk; Ronglih Liao; Rong Tian
Journal:  Circulation       Date:  2009-05-18       Impact factor: 29.690

Review 3.  Glucose Transporters in Cardiac Metabolism and Hypertrophy.

Authors:  Dan Shao; Rong Tian
Journal:  Compr Physiol       Date:  2015-12-15       Impact factor: 9.090

4.  Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin.

Authors:  David S Paul; Trisha J Grevengoed; Florencia Pascual; Jessica M Ellis; Monte S Willis; Rosalind A Coleman
Journal:  Biochim Biophys Acta       Date:  2014-03-12

Review 5.  Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization?

Authors:  Stephen C Kolwicz; Rong Tian
Journal:  Trends Cardiovasc Med       Date:  2009-08       Impact factor: 6.677

6.  Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency.

Authors:  Petras P Dzeja; Kirsten Hoyer; Rong Tian; Song Zhang; Emirhan Nemutlu; Matthias Spindler; Joanne S Ingwall
Journal:  J Physiol       Date:  2011-08-30       Impact factor: 5.182

Review 7.  Energy substrate metabolism in cardiac hypertrophy.

Authors:  Michael F Allard
Journal:  Curr Hypertens Rep       Date:  2004-12       Impact factor: 5.369

8.  Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.

Authors:  Trisha J Grevengoed; Daniel E Cooper; Pamela A Young; Jessica M Ellis; Rosalind A Coleman
Journal:  FASEB J       Date:  2015-07-28       Impact factor: 5.191

Review 9.  Fuel availability and fate in cardiac metabolism: A tale of two substrates.

Authors:  Florencia Pascual; Rosalind A Coleman
Journal:  Biochim Biophys Acta       Date:  2016-03-16

10.  Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats.

Authors:  Christopher R Wilson; Mai K Tran; Katrina L Salazar; Martin E Young; Heinrich Taegtmeyer
Journal:  Biochem J       Date:  2007-09-15       Impact factor: 3.857
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