Literature DB >> 14594297

A novel four-component reaction for the synthesis of functionalised dihydropyrimidines.

Danielle J Vugts1, Helen Jansen, Rob F Schmitz, Frans J J de Kanter, Romano V A Orru.   

Abstract

In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner-Emmons/aza Diels-Alder pathway.

Entities:  

Year:  2003        PMID： 14594297     DOI： 10.1039/b308243a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.

Authors:  Christopher G Evans; Jason E Gestwicki
Journal:  Org Lett       Date:  2009-07-16       Impact factor: 6.005

2.  Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea.

Authors:  Jie-Ping Wan; Yunfang Lin; Kaikai Hu; Yunyun Liu
Journal:  Beilstein J Org Chem       Date:  2014-01-29       Impact factor: 2.883

Review 3.  Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Authors:  Gijs Koopmanschap; Eelco Ruijter; Romano Va Orru
Journal:  Beilstein J Org Chem       Date:  2014-03-04       Impact factor: 2.883

4.  A new paradigm for designing ring construction strategies for green organic synthesis: implications for the discovery of multicomponent reactions to build molecules containing a single ring.

Authors:  John Andraos
Journal:  Beilstein J Org Chem       Date:  2016-11-16       Impact factor: 2.883
  4 in total

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