Literature DB >> 14594094

Taking bisphosphonates during pregnancy.

Amy E French1, Nikolay Kaplan, Michael Lishner, Gideon Koren.   

Abstract

QUESTION: Several of my female patients take bisphosphonates for low bone mineral density (BMD). Two of them are of reproductive age. Are these drugs safe during pregnancy? ANSWER: Very little is currently known about the effects of bisphosphonates on human pregnancy. There have been only two reports of bisphosphonate use during late pregnancy. Animal studies suggest that biphosphonates cross the placenta and that the effect is an extension of the expected pharmacologic effect of bisphosphonates on both fetus and mother. Risks and benefits should be carefully weighed.

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Year:  2003        PMID： 14594094      PMCID： PMC2214129     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  8 in total

1.  Intravenous pamidronate for treatment of reflex sympathetic dystrophy during breast feeding.

Authors:  K Siminoski; A A Fitzgerald; G Flesch; M S Gross
Journal:  J Bone Miner Res       Date:  2000-10       Impact factor: 6.741

2.  Antenatal administration of aminopropylidene diphosphonate.

Authors:  D J Dunlop; M Soukop; H P McEwan
Journal:  Ann Rheum Dis       Date:  1990-11       Impact factor: 19.103

3.  The effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on fetal mice during pregnancy--with emphasis on implantation and fetal weight.

Authors:  Y Sakiyama; I Tada; H Yamamoto; T Nakanishi; Y Yasuda; Y Soeda; M Oda
Journal:  J Osaka Dent Univ       Date:  1986-10

4.  Malignant hypercalcaemia in pregnancy and antenatal administration of intravenous pamidronate.

Authors:  T M Illidge; M Hussey; C W Godden
Journal:  Clin Oncol (R Coll Radiol)       Date:  1996       Impact factor: 4.126

5.  Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats.

Authors:  N Patlas; G Golomb; P Yaffe; T Pinto; E Breuer; A Ornoy
Journal:  Teratology       Date:  1999-08

6.  Reproduction toxicity studies with pamidronate.

Authors:  P Graepel; P Bentley; H Fritz; M Miyamoto; S R Slater
Journal:  Arzneimittelforschung       Date:  1992-05

7.  Effects of the bisphosphonate, alendronate, on parturition in the rat.

Authors:  D H Minsker; J M Manson; C P Peter
Journal:  Toxicol Appl Pharmacol       Date:  1993-08       Impact factor: 4.219

8.  Intravenous reproductive and developmental toxicity studies of cimadronate (YM175), a novel bisphosphonate, in rats and rabbits.

Authors:  A Okazaki; T Matsuzawa; M Takeda; R G York; P C Barrow; V C King; G P Bailey
Journal:  J Toxicol Sci       Date:  1995-10       Impact factor: 2.196
  8 in total
  4 in total

1.  Transient osteoporosis associated with pregnancy: use of bisphosphonate in treating a lactating mother.

Authors:  N G Shenker; M F Shaikh; A S M Jawad
Journal:  BMJ Case Rep       Date:  2010-12-14

2.  Theobromine Upregulates Osteogenesis by Human Mesenchymal Stem Cells In Vitro and Accelerates Bone Development in Rats.

Authors:  Bret H Clough; Joni Ylostalo; Elizabeth Browder; Eoin P McNeill; Thomas J Bartosh; H Ralph Rawls; Tetsuo Nakamoto; Carl A Gregory
Journal:  Calcif Tissue Int       Date:  2016-12-02       Impact factor: 4.333

Review 3.  Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: an update of Brazilian Society of Rheumatology (2020).

Authors:  Rosa M R Pereira; Mariana O Perez; Ana Patrícia Paula; Caio Moreira; Charlles H M Castro; Cristiano A F Zerbini; Diogo S Domiciano; Elaine de Azevedo; Laura M C Mendonca; Marcia Midore Shinzato; Marco Antonio A da Rocha-Loures; Sebastião Radominski; Vera L Szejnfeld
Journal:  Arch Osteoporos       Date:  2021-03-01       Impact factor: 2.617

4.  Seventeen Cases of Primary Hyperparathyroidism in Pregnancy: A Call for Management Guidelines.

Authors:  Aimee Natasha DiMarco; Karim Meeran; Ioannis Christakis; Vinpreet Sodhi; Catherine Nelson-Piercy; Neil Samuel Tolley; Francesco Fausto Palazzo
Journal:  J Endocr Soc       Date:  2019-02-20
  4 in total

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