Literature DB >> 1459398

Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium.

N E Allen1, J N Hobbs, J M Richardson, R M Riggin.   

Abstract

In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin.

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Year:  1992        PMID： 1459398     DOI： 10.1016/0378-1097(92)90140-j

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  21 in total

1.  Peptidoglycan structure of Lactobacillus casei, a species highly resistant to glycopeptide antibiotics.

Authors:  D Billot-Klein; R Legrand; B Schoot; J van Heijenoort; L Gutmann
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

Review 2.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

3.  Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semisynthetic glycopeptide antibiotic.

Authors:  N E Allen; J N Hobbs; T I Nicas
Journal:  Antimicrob Agents Chemother       Date:  1996-10       Impact factor: 5.191

4.  Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States.

Authors:  S Handwerger; J Skoble; L F Discotto; M J Pucci
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

Review 5.  Genetics and mechanisms of glycopeptide resistance in enterococci.

Authors:  M Arthur; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

6.  Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174.

Authors:  P E Reynolds; H A Snaith; A J Maguire; S Dutka-Malen; P Courvalin
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

7.  Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.

Authors:  L Gutmann; S al-Obeid; D Billot-Klein; M L Guerrier; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

8.  Altered peptidoglycan composition in vancomycin-resistant Enterococcus faecalis.

Authors:  B L de Jonge; S Handwerger; D Gage
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

9.  Alterations in peptidoglycan precursors and vancomycin susceptibility in Tn917 insertion mutants of Enterococcus faecalis 221.

Authors:  S Handwerger
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

10.  Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum.

Authors:  D Billot-Klein; L Gutmann; S Sablé; E Guittet; J van Heijenoort
Journal:  J Bacteriol       Date:  1994-04       Impact factor: 3.490
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