Literature DB >> 14593726

Tubulin and microtubules as targets for anticancer drugs.

John A Hadfield1, Sylvie Ducki, Nicholas Hirst, Alan T McGown.   

Abstract

Microtubules are intracellular organelles formed from the protein tubulin. These organelles have a number of essential cellular functions including chromosome segregation, the maintenance of cell shape, transport, motility, and organelle distribution. Drugs that affect the tubulin-microtubule equilibrium (taxol, vinca alkaloids) are effective anticancer drugs. This review describes the molecular target, methods used in screening, the structures of compounds known to interact with tubulin, and the clinical use of these agents. In addition the ability of these agents to destroy tumour vasculature is described. This represents an exciting new molecular target in the design of anticancer drugs.

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Year:  2003        PMID： 14593726

Source DB:  PubMed          Journal:  Prog Cell Cycle Res        ISSN： 1087-2957


  41 in total

1.  MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells.

Authors:  Giampietro Viola; Roberta Bortolozzi; Ernest Hamel; Stefano Moro; Paola Brun; Ignazio Castagliuolo; Maria Grazia Ferlin; Giuseppe Basso
Journal:  Biochem Pharmacol       Date:  2011-09-22       Impact factor: 5.858

2.  Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Olga Cruz-Lopez; Carlota Lopez Cara; Maria Dora Carrion; Andrea Brancale; Ernest Hamel; Longchuan Chen; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

3.  N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.

Authors:  Jonathan A Stefely; Rahul Palchaudhuri; Patricia A Miller; Rebecca J Peterson; Garrett C Moraski; Paul J Hergenrother; Marvin J Miller
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

4.  4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system.

Authors:  Suparna Sengupta; Sasidharan L Smitha; Nisha E Thomas; Thankaiyyan R Santhoshkumar; Satyabhama K C Devi; Kumaran G Sreejalekshmi; Kallikat N Rajasekharan
Journal:  Br J Pharmacol       Date:  2005-08       Impact factor: 8.739

Review 5.  Therapeutic opportunities to control tumor cell cycles.

Authors:  Marcos Malumbres
Journal:  Clin Transl Oncol       Date:  2006-06       Impact factor: 3.405

6.  Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells.

Authors:  Yi-ming Ma; Yu-bo Zhou; Chuan-ming Xie; Dong-mei Chen; Jia Li
Journal:  Acta Pharmacol Sin       Date:  2012-01-23       Impact factor: 6.150

7.  Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2010-06-01       Impact factor: 3.641

8.  Phenethyl isothiocyanate induces cell cycle arrest and reduction of alpha- and beta-tubulin isotypes in human prostate cancer cells.

Authors:  Ping Yin; Tomoya Kawamura; Meilan He; Donkena Krishna Vanaja; Charles Y F Young
Journal:  Cell Biol Int       Date:  2008-10-11       Impact factor: 3.612

9.  Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.

Authors:  Lívia B Salum; Wanessa F Altei; Louise D Chiaradia; Marlon N S Cordeiro; Rafael R Canevarolo; Carolina P S Melo; Evelyn Winter; Bruno Mattei; Hikmat N Daghestani; Maria Cláudia Santos-Silva; Tânia B Creczynski-Pasa; Rosendo A Yunes; José A Yunes; Adriano D Andricopulo; Billy W Day; Ricardo J Nunes; Andreas Vogt
Journal:  Eur J Med Chem       Date:  2013-03-06       Impact factor: 6.514

10.  Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.

Authors:  Elena Porcù; Attila Sipos; Giuseppe Basso; Ernest Hamel; Ruoli Bai; Verena Stempfer; Antal Udvardy; Attila Cs Bényei; Helmut Schmidhammer; Sándor Antus; Giampietro Viola
Journal:  Eur J Med Chem       Date:  2014-07-16       Impact factor: 6.514
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