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Literature DB >> 14593723

The role of the replication licensing system in cell proliferation and cancer.

Abstract

The precise duplication of chromosomal DNA during each cell cycle is essential for the maintenance of genetic stability. Failure to correctly regulate chromosomal DNA replication could lead to losses or duplication of chromosome segments. The precise duplication of chromosomes is normally achieved by correct regulation of the replication licensing system. Here we review our current knowledge of the licensing system and how this might be defective in cancer cells. We also review how detection of licensing components can be used for the diagnosis and prognosis of cancer. Finally we discuss the potential of the replication licensing system as a novel anti-cancer target.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 14593723 PMCID： PMC3604915

Source DB: PubMed Journal: Prog Cell Cycle Res ISSN： 1087-2957

66 in total

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10 in total

1. Preface: chromosomal instability and breast cancer pathogenesis.

Authors: Ashok R Venkitaraman
Journal: J Mammary Gland Biol Neoplasia Date: 2004-07 Impact factor: 2.673

2. The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation.

Authors: Ronald Laskey
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2005-06-29 Impact factor: 6.237

3. Timelines in the insect brain: fates of identified neural stem cells generating the central complex in the grasshopper Schistocerca gregaria.

Authors: George Boyan; Yu Liu
Journal: Dev Genes Evol Date: 2013-12-17 Impact factor: 0.900

4. Glia associated with central complex lineages in the embryonic brain of the grasshopper Schistocerca gregaria.

Authors: Yu Liu; George Boyan
Journal: Dev Genes Evol Date: 2013-03-14 Impact factor: 0.900

5. Ontogeny and development of the tritocerebral commissure giant (TCG): an identified neuron in the brain of the grasshopper Schistocerca gregaria.

Authors: George Stephen Boyan; Leslie Williams; Tobias Müller; Jonathan P Bacon
Journal: Dev Genes Evol Date: 2018-04-17 Impact factor: 0.900

6. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional control over hCdt1.

Authors: Panagiotis Karakaidos; Stavros Taraviras; Leandros V Vassiliou; Panayotis Zacharatos; Nikolaos G Kastrinakis; Dionysia Kougiou; Mirsini Kouloukoussa; Hideo Nishitani; Athanasios G Papavassiliou; Zoi Lygerou; Vassilis G Gorgoulis
Journal: Am J Pathol Date: 2004-10 Impact factor: 4.307

7. Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells.

Authors: Kyle B Jones; Sachiko Furukawa; Pauline Marangoni; Hongfang Ma; Henry Pinkard; Rebecca D'Urso; Rapolas Zilionis; Allon M Klein; Ophir D Klein
Journal: Cell Stem Cell Date: 2018-11-21 Impact factor: 25.269