Literature DB >> 14593717

Inhibitors of the CDC25 phosphatases.

Grégoire Pierre Prevost1, Marie-Christine Brezak, Françoise Goubin, Odile Mondesert, Marie-Odile Galcera, Muriel Quaranta, Frédéric Alby, Olivier Lavergne, Bernard Ducommun.   

Abstract

As essential cell cycle regulators, the CDC25 phosphatases are currently considered as potential targets for the development of novel therapeutic approaches. Here, we review the function and regulation of CDC25 phosphatases, their involvement in cancer and Alzheimer's disease, and the properties of several recently identified inhibitors.

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Year:  2003        PMID: 14593717

Source DB:  PubMed          Journal:  Prog Cell Cycle Res        ISSN: 1087-2957


  8 in total

Review 1.  Therapeutic opportunities to control tumor cell cycles.

Authors:  Marcos Malumbres
Journal:  Clin Transl Oncol       Date:  2006-06       Impact factor: 3.405

2.  Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.

Authors:  Thung-S Lai; Yusha Liu; Tim Tucker; Kurt R Daniel; David C Sane; Eric Toone; James R Burke; Warren J Strittmatter; Charles S Greenberg
Journal:  Chem Biol       Date:  2008-09-22

3.  Toward the virtual screening of Cdc25A phosphatase inhibitors with the homology modeled protein structure.

Authors:  Hwangseo Park; Young Ho Jeon
Journal:  J Mol Model       Date:  2008-05-27       Impact factor: 1.810

4.  Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase.

Authors:  Hua Yang; Shu Zheng; Laurent Meijer; Shi-min Li; Sophie Leclerc; Lin-lin Yu; Jin-quan Cheng; Su-zhan Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2005-07       Impact factor: 3.066

5.  MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.

Authors:  Seung-Ok Lee; Tatyana Masyuk; Patrick Splinter; Jesús M Banales; Anatoliy Masyuk; Angela Stroope; Nicholas Larusso
Journal:  J Clin Invest       Date:  2008-10-23       Impact factor: 14.808

Review 6.  Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies.

Authors:  Natalia Bailon-Moscoso; Gabriela Cevallos-Solorzano; Juan Carlos Romero-Benavides; Maria Isabel Ramirez Orellana
Journal:  Curr Genomics       Date:  2017-04       Impact factor: 2.236

7.  Small interfering RNA targeting CDC25B inhibits liver tumor growth in vitro and in vivo.

Authors:  Xinrui Yan; Mei-Sze Chua; Jing He; Samuel K So
Journal:  Mol Cancer       Date:  2008-02-12       Impact factor: 27.401

8.  Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery.

Authors:  Bao-Zhong Li; Zhao-Li Chen; Su-Sheng Shi; Xiao-Li Feng; Xiao-Gang Tan; Fang Zhou; Jie He
Journal:  Chin J Cancer       Date:  2013-03-08
  8 in total

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