Literature DB >> 14593588

Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis.

J M Rolain1, M N Mallet, D Raoult.   

Abstract

The recommended treatment for Q fever endocarditis is a combination of doxycycline and hydroxychloroquine. We found a correlation between serum doxycycline concentrations and decreases in levels of phase 1 Coxiella burnetii antibodies, in 24 patients with Q fever endocarditis. Patients who had a >2-fold decrease in levels of phase 1 antibodies had serum doxycycline concentrations higher than those of the other patients (mean+/-SD, 5.29+/-1.75 vs. 3.14+/-1.40 microg/mL; P=.003). We recommend adjusting the posology of doxycycline to achieve a serum concentration of at least 5 microg/mL.

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Year:  2003        PMID： 14593588     DOI： 10.1086/379082

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  17 in total

Review 1.  Prospects for gene transfer for clinical heart failure.

Authors:  T Tang; M H Gao; H Kirk Hammond
Journal:  Gene Ther       Date:  2012-04-26       Impact factor: 5.250

2.  Acute Q Fever Case Detection among Acute Febrile Illness Patients, Thailand, 2002-2005.

Authors:  Ashley L Greiner; Saithip Bhengsri; Matthieu Million; Sophie Edouard; Somsak Thamthitiwat; Kevin Clarke; Gilbert J Kersh; Christopher J Gregory; Didier Raoult; Philippe Parola
Journal:  Am J Trop Med Hyg       Date:  2018-01       Impact factor: 2.345

Review 3.  From Q Fever to Coxiella burnetii Infection: a Paradigm Change.

Authors:  Carole Eldin; Cléa Mélenotte; Oleg Mediannikov; Eric Ghigo; Matthieu Million; Sophie Edouard; Jean-Louis Mege; Max Maurin; Didier Raoult
Journal:  Clin Microbiol Rev       Date:  2017-01       Impact factor: 26.132

4.  Q Fever endocarditis: does serology predict outcome?

Authors:  Arístides de Alarcón
Journal:  Curr Infect Dis Rep       Date:  2012-08       Impact factor: 3.725

5.  Correlation between ratio of serum doxycycline concentration to MIC and rapid decline of antibody levels during treatment of Q fever endocarditis.

Authors:  Jean-Marc Rolain; Areen Boulos; Marie-Noëlle Mallet; Didier Raoult
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

Review 6.  Gene transfer for congestive heart failure: update 2013.

Authors:  Tong Tang; H Kirk Hammond
Journal:  Transl Res       Date:  2012-12-20       Impact factor: 7.012

7.  Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics.

Authors:  Ioanna Spyridaki; Anna Psaroulaki; Iosif Vranakis; Yannis Tselentis; Achilleas Gikas
Journal:  Antimicrob Agents Chemother       Date:  2009-03-30       Impact factor: 5.191

8.  Q Fever: current state of knowledge and perspectives of research of a neglected zoonosis.

Authors:  Sarah Rebecca Porter; Guy Czaplicki; Jacques Mainil; Raphaël Guattéo; Claude Saegerman
Journal:  Int J Microbiol       Date:  2011-12-13

9.  Quantitative proteome profiling of C. burnetii under tetracycline stress conditions.

Authors:  Iosif Vranakis; Pieter-Jan De Bock; Anastasia Papadioti; Yannis Tselentis; Kris Gevaert; Georgios Tsiotis; Anna Psaroulaki
Journal:  PLoS One       Date:  2012-03-16       Impact factor: 3.240

10.  The Qure study: Q fever fatigue syndrome--response to treatment; a randomized placebo-controlled trial.

Authors:  Stephan P Keijmel; Corine E Delsing; Tom Sprong; Gijs Bleijenberg; Jos W M van der Meer; Hans Knoop; Chantal P Bleeker-Rovers
Journal:  BMC Infect Dis       Date:  2013-03-27       Impact factor: 3.090
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