Literature DB >> 14593504

Lincomycin, cultivation of producing strains and biosynthesis.

J Spízek1, T Rezanka.   

Abstract

Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice. The chemical structure of lincosamide antibiotics, cultivation of producing strains and analytical procedures used for separation and isolation of these compounds are described in this review. Biosynthesis of lincomycin and related compounds and its genetic control are briefly discussed.

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Year:  2003        PMID： 14593504     DOI： 10.1007/s00253-003-1431-3

Source DB:  PubMed          Journal:  Appl Microbiol Biotechnol        ISSN： 0175-7598            Impact factor:   4.813


  9 in total

1.  The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis.

Authors:  Bingbing Hou; Yanwei Lin; Haizhen Wu; Meijin Guo; Hrvoje Petkovic; Liyuan Tao; Xiaoyu Zhu; Jiang Ye; Huizhan Zhang
Journal:  J Bacteriol       Date:  2017-12-20       Impact factor: 3.490

2.  Catalytic promiscuity of a bacterial α-N-methyltransferase.

Authors:  Qi Zhang; Wilfred A van der Donk
Journal:  FEBS Lett       Date:  2012-07-25       Impact factor: 4.124

Review 3.  The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.

Authors:  Chia-I Lin; Reid M McCarty; Hung-wen Liu
Journal:  Chem Soc Rev       Date:  2013-01-25       Impact factor: 54.564

4.  Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.

Authors:  Eita Sasaki; Chia-I Lin; Ke-Yi Lin; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2012-10-11       Impact factor: 15.419

5.  TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis.

Authors:  Yurong Xu; Meilan Ke; Jie Li; Yaqian Tang; Nian Wang; Guoqing Tan; Yansheng Wang; Ruihua Liu; Linquan Bai; Lixin Zhang; Hang Wu; Buchang Zhang
Journal:  Appl Environ Microbiol       Date:  2018-12-13       Impact factor: 4.792

Review 6.  Actinomycetes: A Never-Ending Source of Bioactive Compounds-An Overview on Antibiotics Production.

Authors:  Davide De Simeis; Stefano Serra
Journal:  Antibiotics (Basel)       Date:  2021-04-22

7.  AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis.

Authors:  Yajing Kang; Yingying Wang; Bingbing Hou; Ruida Wang; Jiang Ye; Xiaoyu Zhu; Haizhen Wu; Huizhan Zhang
Journal:  Front Microbiol       Date:  2019-10-23       Impact factor: 5.640

8.  Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis.

Authors:  Chun-Yan Lin; Ai-Ping Pang; Yue Zhang; Jianjun Qiao; Guang-Rong Zhao
Journal:  Microb Cell Fact       Date:  2020-02-12       Impact factor: 5.328

9.  Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family.

Authors:  Jitka Novotna; Jana Olsovska; Petr Novak; Peter Mojzes; Radka Chaloupkova; Zdenek Kamenik; Jaroslav Spizek; Eva Kutejova; Marketa Mareckova; Pavel Tichy; Jiri Damborsky; Jiri Janata
Journal:  PLoS One       Date:  2013-12-04       Impact factor: 3.240
  9 in total

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