Literature DB >> 14593407

Maintenance of heterochromatin by RNA interference of tandem repeats.

Robert A Martienssen1.   

Abstract

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

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Year:  2003        PMID： 14593407     DOI： 10.1038/ng1252

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  64 in total

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