Literature DB >> 14592919

Mycophenolate mofetil for myasthenia gravis: a double-blind, placebo-controlled pilot study.

Matthew N Meriggioli1, Julie Rowin, Judith G Richman, Sue Leurgans.   

Abstract

Mycophenolate mofetil (MM) is an immunosuppressive agent developed and originally used to prevent acute rejection of solid-organ transplantation. There have been preliminary reports of its successful use in the treatment of autoimmune myasthenia gravis (MG). We conducted a double-blind, placebo-controlled pilot trial of MM in the treatment of suboptimally controlled, stable MG. Results of this pilot study are promising and suggestive of greater improvement in the patients who received MM compared to placebo.

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Year:  2003        PMID: 14592919     DOI: 10.1196/annals.1254.064

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  20 in total

Review 1.  Treatment of myasthenia gravis.

Authors:  Vikas Kumar; Henry J Kaminski
Journal:  Curr Neurol Neurosci Rep       Date:  2011-02       Impact factor: 5.081

2.  Two strikes against mycophenolate mofetil therapy for myasthenia gravis.

Authors:  Michio Hirano
Journal:  Curr Neurol Neurosci Rep       Date:  2009-01       Impact factor: 5.081

3.  A crucial first randomized controlled trial of thymectomy in non-thymomatous myasthenia gravis.

Authors:  Pierre R Bourque; Jodi Warman Chardon
Journal:  J Thorac Dis       Date:  2016-10       Impact factor: 2.895

4.  Mycophenolate mofetil as second line immunosuppressant in Myasthenia gravis--a long-term prospective open-label study.

Authors:  F Hanisch; M Wendt; S Zierz
Journal:  Eur J Med Res       Date:  2009-08-12       Impact factor: 2.175

5.  An Update on Myasthenic Crisis.

Authors:  Shafiuddin Ahmed; Jawad F Kirmani; Nazli Janjua; Ammar Alkawi; Ismail Khatri; Abutaher M Yahia; Nizar Souyah; Adnan I Qureshi
Journal:  Curr Treat Options Neurol       Date:  2005-03       Impact factor: 3.598

Review 6.  Update on myasthenia gravis.

Authors:  B R Thanvi; T C N Lo
Journal:  Postgrad Med J       Date:  2004-12       Impact factor: 2.401

Review 7.  Clinical pharmacokinetics and pharmacodynamics of mycophenolate in patients with autoimmune disease.

Authors:  Azrin N Abd Rahman; Susan E Tett; Christine E Staatz
Journal:  Clin Pharmacokinet       Date:  2013-05       Impact factor: 6.447

8.  Myasthenia Gravis.

Authors:  Michael Graves; Jonathan S. Katz
Journal:  Curr Treat Options Neurol       Date:  2004-03       Impact factor: 3.598

Review 9.  Advances in autoimmune myasthenia gravis management.

Authors:  Shuhui Wang; Iva Breskovska; Shreya Gandhy; Anna Rostedt Punga; Jeffery T Guptill; Henry J Kaminski
Journal:  Expert Rev Neurother       Date:  2018-07-04       Impact factor: 4.618

10.  Mycophenolate mofetil for myasthenia gravis: a clear and present controversy.

Authors:  Chad Heatwole; Emma Ciafaloni
Journal:  Neuropsychiatr Dis Treat       Date:  2008-12       Impact factor: 2.570

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