Literature DB >> 14592804

Vitamin C contributes to inflammation via radical generating mechanisms: a cautionary note.

A E O Fisher1, D P Naughton.   

Abstract

Reactive oxygen and nitrogen species (RONS) have been ascribed an important role in oxidative stress contributing to the progression of inflammatory diseases such as Crohn's disease and rheumatoid arthritis. Redox-active metal ions such as Fe(II) and Cu(I) further activate RONS and thus perpetuate their damaging effects. High intake of ascorbic acid exerts a pro-oxidant effect by its interaction with metal ions via a number of established RONS generating systems. Caution should be exerted regarding surplus ascorbic acid intake for patients with chronic inflammatory diseases.

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Year:  2003        PMID： 14592804     DOI： 10.1016/s0306-9877(03)00271-8

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  6 in total

Review 1.  Antioxidants in multiple sclerosis: do they have a role in therapy?

Authors:  Noel G Carlson; John W Rose
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C.

Authors:  Wang-Sheng Ko; Chih-Hung Guo; Maw-Sheng Yeh; Li-Yun Lin; Guoo-Shyng W Hsu; Pei-Chung Chen; Mei-Ching Luo; Chia-Yeh Lin
Journal:  World J Gastroenterol       Date:  2005-08-14       Impact factor: 5.742

3.  Protective effects of manganese(II) chloride on hyaluronan degradation by oxidative system ascorbate plus cupric chloride.

Authors:  Katarína Valachová; Grigorij Kogan; Peter Gemeiner; Ladislav Soltés
Journal:  Interdiscip Toxicol       Date:  2010-03-29

4.  Catabolism of hyaluronan: involvement of transition metals.

Authors:  Ladislav Soltés; Grigorij Kogan
Journal:  Interdiscip Toxicol       Date:  2009-12-28

5.  EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE.

Authors:  Ricardo Guimarães Marim; Alex Silva de Gusmão; Roberto Esteves Pires Castanho; Rafael Deminice; Altino Luiz Silva Therezo; Alceu Afonso Jordão Júnior; Marcos Renato de Assis; Elane de Fátima Taipeiro; Luciamare Perinetti Alves Martins
Journal:  Rev Inst Med Trop Sao Paulo       Date:  2015 May-Jun       Impact factor: 1.846

Review 6.  A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis.

Authors:  Matin Khosravi-Largani; Parmida Pourvali-Talatappeh; Ali Mohammad Rousta; Maedeh Karimi-Kivi; Elahe Noroozi; Ali Mahjoob; Yasaman Asaadi; Alireza Shahmohammadi; Sarina Sadeghi; Shiva Shakeri; Kimiya Ghiyasvand; Masoumeh Tavakoli-Yaraki
Journal:  eNeurologicalSci       Date:  2018-01-28
  6 in total

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