| Literature DB >> 14592522 |
Xingliang Lu1, Dejan Nikolic, Deanna J Mitchell, Richard B van Breemen, John A Mersfelder, Russ Hille, Richard B Silverman.
Abstract
Experiments are described to determine the origin of the 6-hydroxyl group of 6-hydroxyFMN produced by the substrate-induced transformation of FMN in the C30A mutant of trimethylamine dehydrogenase. The conversion of FMN to 6-hydroxyFMN is carried out in the presence of H(2)(18)O and 18O(2), and the results clearly show that the 6-hydroxyl group is derived from molecular oxygen and not from water.Entities:
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Year: 2003 PMID： 14592522 DOI： 10.1016/j.bmcl.2003.07.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823