| Literature DB >> 14592513 |
Hidekazu Masaki1, Yusuke Mizuno, Akira Tatui, Akira Murakami, Yuuki Koide, Shoji Satoh, Atsuo Takahashi.
Abstract
We have identified a new class of chymase inhibitor through a substituent analysis of MWP00965, which we previously discovered by in silico screening. TY-51076 (7) showed high potency (IC(50)=56 nM) and excellent selectivity for chymase compared to chymotrypsin and cathepsin G (>400-fold). The synthesis and structure-activity relationship of this class are described.Entities:
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Year: 2003 PMID： 14592513 DOI： 10.1016/j.bmcl.2003.08.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823