| Literature DB >> 14592510 |
Pierre-Yves Michellys1, Marcus F Boehm, Jyun-Hung Chen, Timothy A Grese, Donald S Karanewsky, Mark D Leibowitz, Sha Liu, Dale A Mais, Christopher M Mapes, Anne Reifel-Miller, Katheen M Ogilvie, Deepa Rungta, Anthony W Thompson, John S Tyhonas, Nathan Yumibe, Robert J Ardecky.
Abstract
New RXR-selective modulators possessing a 6-fluoro trienoic acid moiety (6Z olefin) or a fluorinated/heterocyclic-substituted benzene core ring, were synthesized in an expedient and selective way. A subset of these compounds was evaluated for their metabolic properties (exposure in IRC male mice) and show a dramatic increase of exposure compared to our reference compound, 3 (LG101506).Entities:
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Year: 2003 PMID： 14592510 DOI： 10.1016/j.bmcl.2003.08.048
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823