| Literature DB >> 14592504 |
L Alcaraz1, A Baxter, J Bent, K Bowers, M Braddock, D Cladingboel, D Donald, M Fagura, M Furber, C Laurent, M Lawson, M Mortimore, M McCormick, N Roberts, M Robertson.
Abstract
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notably the macrophage, mast cell and lymphocyte, suggests that P2X(7) antagonists have a significant role to play in the treatment of inflammatory disease.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14592504 DOI： 10.1016/j.bmcl.2003.08.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823