| Literature DB >> 14592500 |
Nancy J Kevin1, Joseph L Duffy, Brian A Kirk, Kevin T Chapman, William A Schleif, David B Olsen, Mark Stahlhut, Carrie A Rutkowski, Lawrence C Kuo, Lixia Jin, Jiunn H Lin, Emilio A Emini, James R Tata.
Abstract
HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P(3) position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.Entities:
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Year: 2003 PMID： 14592500 DOI： 10.1016/j.bmcl.2003.08.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823