Literature DB >> 14592496

11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.

J R Falck1, L Manmohan Reddy, Y Krishna Reddy, Muralidhar Bondlela, U Murali Krishna, Yu Ji, Jianxin Sun, James K Liao.   

Abstract

A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.

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Year:  2003        PMID： 14592496     DOI： 10.1016/j.bmcl.2003.08.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  32 in total

Review 1.  Targeting epoxides for organ damage in hypertension.

Authors:  John D Imig
Journal:  J Cardiovasc Pharmacol       Date:  2010-10       Impact factor: 3.105

2.  The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.

Authors:  Yindi Ding; Timo Frömel; Rüdiger Popp; John R Falck; Wolf-Hagen Schunck; Ingrid Fleming
Journal:  J Pharmacol Exp Ther       Date:  2014-04-24       Impact factor: 4.030

3.  Soluble epoxide hydrolase is a therapeutic target for acute inflammation.

Authors:  Kara R Schmelzer; Lukas Kubala; John W Newman; In-Hae Kim; Jason P Eiserich; Bruce D Hammock
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-30       Impact factor: 11.205

4.  Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Authors:  Eiichi Hasegawa; Saori Inafuku; Lama Mulki; Yoko Okunuki; Ryoji Yanai; Kaylee E Smith; Clifford B Kim; Garrett Klokman; Diane R Bielenberg; Narender Puli; John R Falck; Deeba Husain; Joan W Miller; Matthew L Edin; Darryl C Zeldin; Kin Sing Stephen Lee; Bruce D Hammock; Wolf-Hagen Schunck; Kip M Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

Review 5.  Epoxides and soluble epoxide hydrolase in cardiovascular physiology.

Authors:  John D Imig
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

Review 6.  Rationally designed multitarget agents against inflammation and pain.

Authors:  S H Hwang; A T Wecksler; K Wagner; B D Hammock
Journal:  Curr Med Chem       Date:  2013       Impact factor: 4.530

7.  Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia.

Authors:  Ines P Koerner; Wenri Zhang; Jian Cheng; Susan Parker; Patricia D Hurn; Nabil J Alkayed
Journal:  Front Biosci       Date:  2008-01-01

8.  20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.

Authors:  Yuenmu Chen; John R Falck; Venugopal R Tuniki; William B Campbell
Journal:  J Pharmacol Exp Ther       Date:  2009-09-17       Impact factor: 4.030

9.  Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.

Authors:  Md Abdul Hye Khan; Jing Liu; Ganesh Kumar; Stephen X Skapek; John R Falck; John D Imig
Journal:  FASEB J       Date:  2013-04-19       Impact factor: 5.191

10.  14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

Authors:  J R Falck; Ravinder Kodela; Rajkumar Manne; Krishnam Raju Atcha; Narender Puli; Narsimhaswamy Dubasi; Vijay L Manthati; Jorge H Capdevila; Xiu-Yu Yi; Daniel H Goldman; Christophe Morisseau; Bruce D Hammock; William B Campbell
Journal:  J Med Chem       Date:  2009-08-27       Impact factor: 7.446
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