| Literature DB >> 14592495 |
John Wityak1, Jagabandhu Das, Robert V Moquin, Zhongqi Shen, James Lin, Ping Chen, Arthur M Doweyko, Sidney Pitt, Suhong Pang, Ding Ren Shen, Qiong Fang, Henry F de Fex, Gary L Schieven, Steven B Kanner, Joel C Barrish.
Abstract
A novel series of 2-amino-5-carboxamidothiazoles were identified as inhibitors of Lck. Structure-activity studies demonstrate the structural requirements for potent Lck activity. Cyclopropylamide 11d is a potent Lck inhibitor having sub-micromolar activity in a PBL proliferation assay.Entities:
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Year: 2003 PMID： 14592495 DOI： 10.1016/j.bmcl.2003.08.054
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823