| Literature DB >> 14592487 |
Tomohiko Ohwada1, Taro Nonomura, Keisuke Maki, Kazuho Sakamoto, Susumu Ohya, Katsuhiko Muraki, Yuji Imaizumi.
Abstract
We found that the dehydroabietic acid structure is a new scaffold for chemical modulators of large-conductance calcium-activated K+ channels (BK channels). Structure-activity relationship (SAR) studies of the dehydroabietic acid derivatives and related non-aromatic compounds such as pimaric acid revealed the importance of the carboxyl functionality and an appropriate hydrophobic moiety of the molecules for BK channel-opening ability.Entities:
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Year: 2003 PMID： 14592487 DOI： 10.1016/j.bmcl.2003.08.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823