| Literature DB >> 14592476 |
Fei Yin1, Jianhui Liu, Xiaojun Peng.
Abstract
Telomerase inhibition can be achieved by stabilization of G-quadruplex structure. Triethylene tetraamine, a small linear molecule, has been identified as a potent telomerase inhibitor. It stabilizes both intra- and inter-molecular G-quadruplexes and shows a good differential between potent telomerase inhibition and acute cytotoxicity.Entities:
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Year: 2003 PMID： 14592476 DOI： 10.1016/j.bmcl.2003.09.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823