Methodologic issues in neuropsychological research with HIV-spectrum disease.

Conflicting data have emerged from the initial studies of the neuropsychogical sequelae of human immunodeficiency virus (HIV) infection. This paper reviews key methodologic issues that must be addressed when embarking upon new research on the neuropsychology of HIV spectrum disease. Finally, suggestions are given for methodologic pitfalls to be avoided when conducting or interpreting research in this domain.