Literature DB >> 1458682

Glomerular immune deposits in murine lupus models may contain histones.

T Schmiedeke1, F Stoeckl, S Muller, Y Sugisaki, S Batsford, R Woitas, A Vogt.   

Abstract

Two types of lupus mice, NZB/NZW F1 female hybrids and mice with graft-versus-host disease (GVHD), were studied. Histones H3 and H2A were detected by immunofluorescence in glomeruli of 22/22 proteinuric GVHD and 8/12 proteinuric NZB/W F1 female mice; in non-proteinuric animals, 3/5 GVHD and 2/27 NZB/W F1 female were positive. Using antibodies to histone peptides it was shown that mainly the N-terminal regions of histones H3 and H2A were exposed in glomerular deposits. Western blot analysis revealed antibodies to histone subfractions in sera of 33/34 lupus mice that developed proteinuria. This study provides evidence that histones are involved in the pathogenesis of lupus nephritis.

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Year:  1992        PMID： 1458682      PMCID： PMC1554586          DOI： 10.1111/j.1365-2249.1992.tb05867.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  24 in total

1.  Double reactivity of monoclonal and polyclonal rheumatoid factors for IgG and histones: mapping of binding sites by means of histone synthetic peptides and anti-Id antibodies.

Authors:  N Tuaillon; T Martin; A M Knapp; J L Pasquali; S Muller
Journal:  J Autoimmun       Date:  1992-02       Impact factor: 7.094

2.  Accessibility and structural role of histone domains in chromatin. biophysical and immunochemical studies of progressive digestion with immobilized proteases.

Authors:  M F Hacques; S Muller; G De Murcia; M H Van Regenmortel; C Marion
Journal:  J Biomol Struct Dyn       Date:  1990-12

3.  Immunogenicity of free histones and of histones complexed with RNA.

Authors:  S Muller; M L Chaix; J P Briand; M H Van Regenmortel
Journal:  Mol Immunol       Date:  1991-07       Impact factor: 4.407

4.  Comparison of different methods for localizing antigenic regions in histone H2A.

Authors:  S Muller; S Plaue; M Couppez; M H Van Regenmortel
Journal:  Mol Immunol       Date:  1986-06       Impact factor: 4.407

5.  Selective production of autoantibodies in graft-vs-host-induced and spontaneous murine lupus. Predominant reactivity with histone regions accessible in chromatin.

Authors:  J P Portanova; R E Arndt; B L Kotzin
Journal:  J Immunol       Date:  1988-02-01       Impact factor: 5.422

6.  Iodination of nucleic acids in vitro.

Authors:  S L Commerford
Journal:  Biochemistry       Date:  1971-05-25       Impact factor: 3.162

7.  Studies on histones. 7. Preparative methods for histone fractions from calf thymus.

Authors:  E W Johns
Journal:  Biochem J       Date:  1964-07       Impact factor: 3.857

8.  Cross-reactivity of monoclonal anti-DNA antibodies with heparan sulfate is mediated via bound DNA/histone complexes.

Authors:  R M Termaat; K Brinkman; F van Gompel; L P van den Heuvel; J H Veerkamp; R J Smeenk; J H Berden
Journal:  J Autoimmun       Date:  1990-10       Impact factor: 7.094

9.  Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.

Authors:  P Faaber; T P Rijke; L B van de Putte; P J Capel; J H Berden
Journal:  J Clin Invest       Date:  1986-06       Impact factor: 14.808

10.  A branched, synthetic octapeptide of ubiquitinated histone H2A as target of autoantibodies.

Authors:  S Plaué; S Muller; M H van Regenmortel
Journal:  J Exp Med       Date:  1989-05-01       Impact factor: 14.307
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  13 in total

Review 1.  Anti-DNA, antihistone, and antinucleosome antibodies in systemic lupus erythematosus and drug-induced lupus.

Authors:  G Q Shen; Y Shoenfeld; J B Peter
Journal:  Clin Rev Allergy Immunol       Date:  1998       Impact factor: 8.667

2.  Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis.

Authors:  M Soto; J M Requena; L Quijada; M J Perez; C G Nieto; F Guzman; M E Patarroyo; C Alonso
Journal:  Clin Exp Immunol       Date:  1999-02       Impact factor: 4.330

3.  Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction.

Authors:  Mark R Gillrie; Kristine Lee; D Channe Gowda; Shevaun P Davis; Marc Monestier; Liwang Cui; Tran Tinh Hien; Nicholas P J Day; May Ho
Journal:  Am J Pathol       Date:  2012-01-17       Impact factor: 4.307

4.  Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.

Authors:  T J Vyse; C G Drake; S J Rozzo; E Roper; S Izui; B L Kotzin
Journal:  J Clin Invest       Date:  1996-10-15       Impact factor: 14.808

5.  Higher anti-heparan sulphate reactivity during systemic lupus erythematosus (SLE) disease exacerbations with renal manifestations; a long term prospective analysis.

Authors:  C Kramers; R M Termaat; E J ter Borg; M C van Bruggen; C G Kallenberg; J H Berden
Journal:  Clin Exp Immunol       Date:  1993-07       Impact factor: 4.330

6.  Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus.

Authors:  J B Lefkowith; M Kiehl; J Rubenstein; R DiValerio; K Bernstein; L Kahl; R L Rubin; M Gourley
Journal:  J Clin Invest       Date:  1996-09-15       Impact factor: 14.808

7.  Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes.

Authors:  L F Pereira; F M Marco; R Boimorto; A Caturla; A Bustos; E G De la Concha; J L Subiza
Journal:  Clin Exp Immunol       Date:  1994-08       Impact factor: 4.330

8.  Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

Authors:  C Kramers; M N Hylkema; M C van Bruggen; R van de Lagemaat; H B Dijkman; K J Assmann; R J Smeenk; J H Berden
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

9.  Serologic markers of lupus nephritis in patients: use of a tissue-based ELISA and evidence for immunopathogenic heterogeneity.

Authors:  K A Bernstein; L E Kahl; J E Balow; J B Lefkowith
Journal:  Clin Exp Immunol       Date:  1994-10       Impact factor: 4.330

10.  Decrease of heparan sulfate staining in the glomerular basement membrane in murine lupus nephritis.

Authors:  M C van Bruggen; K Kramers; M N Hylkema; J van den Born; M A Bakker; K J Assmann; R J Smeenk; J H Berden
Journal:  Am J Pathol       Date:  1995-03       Impact factor: 4.307
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