BACKGROUND/AIMS: The antigen phenotype of human osteoblast-like cells suggests that they are related to other cellular populations and may also have immunologic functions in common. METHODS: Flow cytometry and transmission electron microscopy were used to show the phagocytotic activity of osteoblast-like cells in culture. The allogeneic stimulation of T cells by human osteoblast-like cells was determined by the measurement of T cell proliferation. RESULTS: We demonstrated in vitro that human osteoblast-like cells isolated from normal bone specimens obtained during mandibular osteotomy can phagocytose particles of different nature and size and can stimulate allogeneic T cells. Phagocytosis of microorganisms (E.coli, Klebsiella or C. albicans) was observed, although at a very low rate of activity in comparison with the phagocytosis of latex particles. CONCLUSION: Our results suggest that human osteoblast-like cells may perform immunologic functions and act as antigen presentation cells. Copyright 2003 S. Karger AG, Basel
BACKGROUND/AIMS: The antigen phenotype of human osteoblast-like cells suggests that they are related to other cellular populations and may also have immunologic functions in common. METHODS: Flow cytometry and transmission electron microscopy were used to show the phagocytotic activity of osteoblast-like cells in culture. The allogeneic stimulation of T cells by human osteoblast-like cells was determined by the measurement of T cell proliferation. RESULTS: We demonstrated in vitro that human osteoblast-like cells isolated from normal bone specimens obtained during mandibular osteotomy can phagocytose particles of different nature and size and can stimulate allogeneic T cells. Phagocytosis of microorganisms (E.coli, Klebsiella or C. albicans) was observed, although at a very low rate of activity in comparison with the phagocytosis of latex particles. CONCLUSION: Our results suggest that human osteoblast-like cells may perform immunologic functions and act as antigen presentation cells. Copyright 2003 S. Karger AG, Basel
Authors: C Ruiz; E Pérez; O García-Martínez; L Díaz-Rodríguez; M Arroyo-Morales; C Reyes-Botella Journal: J Bone Miner Metab Date: 2007-08-25 Impact factor: 2.626
Authors: Rosa Medina-Huertas; Francisco Javier Manzano-Moreno; Elvira De Luna-Bertos; Javier Ramos-Torrecillas; Olga García-Martínez; Concepción Ruiz Journal: Lasers Med Sci Date: 2014-03-12 Impact factor: 3.161
Authors: Francisco Javier Manzano-Moreno; Javier Ramos-Torrecillas; Elvira De Luna-Bertos; Candela Reyes-Botella; Concepción Ruiz; Olga García-Martínez Journal: Clin Oral Investig Date: 2014-08-28 Impact factor: 3.573
Authors: Lucía Melguizo-Rodríguez; Javier Ramos-Torrecillas; Francisco Javier Manzano-Moreno; Rebeca Illescas-Montes; Ana Rivas; Concepción Ruiz; Elvira De Luna-Bertos; Olga García-Martínez Journal: PLoS One Date: 2018-04-26 Impact factor: 3.240