Literature DB >> 1458544

Block copolymers as drug carriers.

M Yokoyama1.   

Abstract

The main subject of this review is to describe the concept and strategy of utilizing block copolymers as drug carriers and to present a perspective for this utilization. The first section points out preferable properties of block copolymers as drug carriers with a brief survey on classifications and synthesis of block copolymers and specifies the merits of block copolymers for this purpose in the historical background of polymeric drug carriers. The second section introduces several studies using block copolymers as drug carriers. These studies contain surface modification of microspheres with block copolymers, polymeric micelles, and a conjugate of an antibody and block copolymer. In conclusion, it is determined that block copolymers possess a high potential for use as drug carriers irrespective of some difficulties in their synthesis.

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Year:  1992        PMID: 1458544

Source DB:  PubMed          Journal:  Crit Rev Ther Drug Carrier Syst        ISSN: 0743-4863            Impact factor:   4.889


  11 in total

1.  An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.

Authors:  Xiankai Sun; Raffaella Rossin; Jeffrey L Turner; Matthew L Becker; Maisie J Joralemon; Michael J Welch; Karen L Wooley
Journal:  Biomacromolecules       Date:  2005 Sep-Oct       Impact factor: 6.988

Review 2.  Drug targeting with nano-sized carrier systems.

Authors:  Masayuki Yokoyama
Journal:  J Artif Organs       Date:  2005       Impact factor: 1.731

Review 3.  Disposition of drugs in block copolymer micelle delivery systems: from discovery to recovery.

Authors:  Hamidreza Montazeri Aliabadi; Mostafa Shahin; Dion R Brocks; Afsaneh Lavasanifar
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

4.  Synthesis and characterization of graft copolymer of chitosan and polyethylene glycol.

Authors:  Yan Zhao; Yiyi Sun; Zhihe Zang; Xiaohong Xu; Zhonglin Zhang; Ling Zhong; Wang Zan; Yan Zhao; Lin Sun
Journal:  Mol Biol Rep       Date:  2010-11-23       Impact factor: 2.316

Review 5.  Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval.

Authors:  Duhyeong Hwang; Jacob D Ramsey; Alexander V Kabanov
Journal:  Adv Drug Deliv Rev       Date:  2020-09-24       Impact factor: 15.470

Review 6.  Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery.

Authors:  Lilian E van Vlerken; Tushar K Vyas; Mansoor M Amiji
Journal:  Pharm Res       Date:  2007-03-29       Impact factor: 4.200

7.  Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel.

Authors:  Xiaolan Zhang; Ke Liu; Yixian Huang; Jieni Xu; Jiang Li; Xiaochao Ma; Song Li
Journal:  Bioconjug Chem       Date:  2014-08-14       Impact factor: 4.774

Review 8.  Recent trends of polymer mediated liposomal gene delivery system.

Authors:  Shyamal Kumar Kundu; Ashish Ranjan Sharma; Sang-Soo Lee; Garima Sharma; C George Priya Doss; Shin Yagihara; Do-Young Kim; Ju-Suk Nam; Chiranjib Chakraborty
Journal:  Biomed Res Int       Date:  2014-08-27       Impact factor: 3.411

9.  Stealth properties to improve therapeutic efficacy of drug nanocarriers.

Authors:  Stefano Salmaso; Paolo Caliceti
Journal:  J Drug Deliv       Date:  2013-03-07

10.  Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs.

Authors:  Wei Xu; Peixue Ling; Tianmin Zhang
Journal:  J Drug Deliv       Date:  2013-06-27
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