Literature DB >> 14584931

Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate.

Arturo Battaglia1, Ralph J Bernacki, Carlo Bertucci, Ezio Bombardelli, Samanta Cimitan, Cristiano Ferlini, Gabriele Fontana, Andrea Guerrini, Antonella Riva.   

Abstract

A series of 2'-methyl taxoids were synthesized and essayed for growth inhibition experiments conducted in human ovarian cancer cell line A2780wt and its counterparts A2780cis, A2780tax, and A2780adr, resistant to cisplatin, paclitaxel, and doxorubicin, respectively, to test the effect of this substituent on the antitumor activity. Additional experiments were performed on MCF-7 human breast cancer cell line and MCF7-R resistant to doxorubicin. In several cases these taxoids were more active than paclitaxel showing subnanomolar IC(50) values.

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Year:  2003        PMID： 14584931     DOI： 10.1021/jm034146v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

Authors:  Bernard L Flynn; Gurmit S Gill; Damian W Grobelny; Jason H Chaplin; Dharam Paul; Annabell F Leske; Tina C Lavranos; David K Chalmers; Susan A Charman; Edmund Kostewicz; David M Shackleford; Julia Morizzi; Ernest Hamel; M Katherine Jung; Gabriel Kremmidiotis
Journal:  J Med Chem       Date:  2011-08-05       Impact factor: 7.446

2.  A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery.

Authors:  Clive Yik-Sham Chung; Sin-Ki Fung; Ka-Chung Tong; Pui-Ki Wan; Chun-Nam Lok; Yanyu Huang; Tianfeng Chen; Chi-Ming Che
Journal:  Chem Sci       Date:  2016-11-22       Impact factor: 9.825

3.  Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position.

Authors:  Monika Skibińska; Marcin Kaźmierczak; Thierry Milcent; Tomasz Cytlak; Henryk Koroniak; Benoit Crousse
Journal:  Front Chem       Date:  2019-08-06       Impact factor: 5.221

4.  Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.

Authors:  Mirko Andreoli; Marco Persico; Ajay Kumar; Nausicaa Orteca; Vineet Kumar; Antonella Pepe; Sakkarapalayam Mahalingam; Antonio E Alegria; Lella Petrella; Laima Sevciunaite; Alessia Camperchioli; Marisa Mariani; Antonio Di Dato; Ettore Novellino; Giovanni Scambia; Sanjay V Malhotra; Cristiano Ferlini; Caterina Fattorusso
Journal:  J Med Chem       Date:  2014-09-26       Impact factor: 7.446
  4 in total

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