Primary squamous cell carcinoma of the breast.

Primary squamous cell carcinoma of the breast is a rare neoplasm. We herein report two cases of primary squamous cell carcinoma of the breast, each with a different clinical manifestation. A 75-year-old patient with bilateral breast cancer and a 73-year-old woman with a mastitis carcinomatosa. Histopathology revealed that both tumours were squamous cell carcinomas. In the first case there was a coexisting adenocarcinoma in the contralateral breast. The diagnostic and therapeutic challenges are discussed in a review of the literature. The initial management of primary squamous cell carcinoma should be slightly different to that of more common types of breast cancer.