Literature DB >> 14583386

Vagus nerve stimulation attenuates heat- and formalin-induced pain in rats.

C Bohotin1, M Scholsem, V Bohotin, R Franzen, J Schoenen.   

Abstract

The analgesic effect of vagus nerve stimulation (VNS) has not yet been demonstrated in animals with the devices used in the clinic. We studied in awake rats the effects of two VNS protocols on the hind paw hot water test and compared the results with those previously obtained in the oro-facial formalin test. A stringent duty cycle (20 s on/18 s off) increased heat pain tolerance in both hind paws (average 188%) after 2 h of stimulation. VNS with parameters used in epilepsy (30 s on/5 min off) decreased heat tolerance after 2 h, but produced a significant antinociceptive effect after days of stimulation. VNS may thus be useful in pain disorders, even with the less stringent protocol.

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Year:  2003        PMID： 14583386     DOI： 10.1016/s0304-3940(03)00908-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Evidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers.

Authors:  Romain Nonis; Kevin D'Ostilio; Jean Schoenen; Delphine Magis
Journal:  Cephalalgia       Date:  2017-06-26       Impact factor: 6.292

Review 2.  Current Directions in the Auricular Vagus Nerve Stimulation I - A Physiological Perspective.

Authors:  Eugenijus Kaniusas; Stefan Kampusch; Marc Tittgemeyer; Fivos Panetsos; Raquel Fernandez Gines; Michele Papa; Attila Kiss; Bruno Podesser; Antonino Mario Cassara; Emmeric Tanghe; Amine Mohammed Samoudi; Thomas Tarnaud; Wout Joseph; Vaidotas Marozas; Arunas Lukosevicius; Niko Ištuk; Antonio Šarolić; Sarah Lechner; Wlodzimierz Klonowski; Giedrius Varoneckas; Jozsef Constantin Széles
Journal:  Front Neurosci       Date:  2019-08-09       Impact factor: 4.677

3.  Differential efficacy of non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A meta-analysis.

Authors:  Ilse F de Coo; Juana Ca Marin; Stephen D Silberstein; Deborah I Friedman; Charly Gaul; Candace K McClure; Alok Tyagi; Eric Liebler; Stewart J Tepper; Michel D Ferrari; Peter J Goadsby
Journal:  Cephalalgia       Date:  2019-06-10       Impact factor: 6.292

Review 4.  Molecular Aspects of Regional Pain Syndrome.

Authors:  Manuela Baronio; Hajra Sadia; Stefano Paolacci; Domenico Prestamburgo; Danilo Miotti; Vittorio A Guardamagna; Giuseppe Natalini; Stephanie G B Sullivan; Matteo Bertelli
Journal:  Pain Res Manag       Date:  2020-04-11       Impact factor: 3.037

5.  Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation.

Authors:  Xiaodan Shi; Yedong Hu; Bo Zhang; Wenna Li; Jiande Dz Chen; Fei Liu
Journal:  JCI Insight       Date:  2021-07-22
  5 in total

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