Literature DB >> 14582532

Mammalian telomeres and telomerase: why they matter for cancer and aging.

María A Blasco1.   

Abstract

Chromosome ends, or telomeres, are formed by a special chromatin structure that protects them from recombination and degradation, thus preventing end-to-end chromosome fusions and other chromosomal aberrations. The functionality of telomeres, and that of the cellular activity that synthesizes them, telomerase, has been shown to impact on both cancer and aging, as well as on the organismal sensitivity to ionizing radiation. This review focuses on the analysis of different mouse models for proteins that are important for telomere function, which have highlighted the importance of telomeres and telomerase for cancer and aging.

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Year:  2003        PMID： 14582532     DOI： 10.1078/0171-9335-00335

Source DB:  PubMed          Journal:  Eur J Cell Biol        ISSN： 0171-9335            Impact factor:   4.492


  19 in total

1.  Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.

Authors:  Karin A Mattern; Susan J J Swiggers; Alex L Nigg; Bob Löwenberg; Adriaan B Houtsmuller; J Mark J M Zijlmans
Journal:  Mol Cell Biol       Date:  2004-06       Impact factor: 4.272

2.  Mapping of a major locus that determines telomere length in humans.

Authors:  Mariuca Vasa-Nicotera; Scott Brouilette; Massimo Mangino; John R Thompson; Peter Braund; Jenny-Rebecca Clemitson; Andrea Mason; Clare L Bodycote; Stuart M Raleigh; Edward Louis; Nilesh J Samani
Journal:  Am J Hum Genet       Date:  2004-11-01       Impact factor: 11.025

3.  Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities.

Authors:  Jörg S Hartig; Eric T Kool
Journal:  Nucleic Acids Res       Date:  2004-11-01       Impact factor: 16.971

4.  Copper(ii) l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity.

Authors:  Farukh Arjmand; Surbhi Sharma; Sabiha Parveen; Loic Toupet; Zhen Yu; James Allan Cowan
Journal:  Dalton Trans       Date:  2020-07-21       Impact factor: 4.390

5.  Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.

Authors:  Kan Cao; Cecilia D Blair; Dina A Faddah; Julia E Kieckhaefer; Michelle Olive; Michael R Erdos; Elizabeth G Nabel; Francis S Collins
Journal:  J Clin Invest       Date:  2011-06-13       Impact factor: 14.808

6.  POT1 and TRF2 cooperate to maintain telomeric integrity.

Authors:  Qin Yang; Yun-Ling Zheng; Curtis C Harris
Journal:  Mol Cell Biol       Date:  2005-02       Impact factor: 4.272

7.  Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.

Authors:  Douglas X Mason; Daniel Keppler; Jun Zhang; Tonya J Jackson; Yvette R Seger; Seiichi Matsui; Fleurette Abreo; John K Cowell; Gregory J Hannon; Scott W Lowe; Athena W Lin
Journal:  Carcinogenesis       Date:  2005-11-09       Impact factor: 4.944

8.  Genetic variants in telomere-maintaining genes and skin cancer risk.

Authors:  Hongmei Nan; Abrar A Qureshi; Jennifer Prescott; Immaculata De Vivo; Jiali Han
Journal:  Hum Genet       Date:  2010-11-30       Impact factor: 4.132

9.  Mechanism of telomerase activation by v-Rel and its contribution to transformation.

Authors:  Radmila Hrdlicková; Jirí Nehyba; Andrew S Liss; Henry R Bose
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

10.  TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs.

Authors:  Hyeung Kim; Ok-Hee Lee; Huawei Xin; Liuh-Yow Chen; Jun Qin; Heekyung Kate Chae; Shiaw-Yih Lin; Amin Safari; Dan Liu; Zhou Songyang
Journal:  Nat Struct Mol Biol       Date:  2009-03-15       Impact factor: 15.369
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