Literature DB >> 14581575

Requirement of varicella-zoster virus immediate-early 4 protein for viral replication.

Bunji Sato1, Marvin Sommer, Hideki Ito, Ann M Arvin.   

Abstract

Varicella-zoster virus (VZV) is an alphaherpesvirus that causes two diseases, chickenpox and zoster. VZV open reading frame 4 (ORF4) encodes the immediate-early 4 (IE4) protein, which is conserved among alphaherpesvirus and has transactivation activity in transient transfections. To determine whether the ORF4 gene product is essential for viral replication, we used VZV cosmids to remove ORF4 from the VZV genome. Deleting ORF4 was incompatible with recovery of infectious virus, whereas transfections done by using repaired cosmids with ORF4 inserted at a nonnative site yielded virus. To analyze the functional domain of IE4, we introduced a mutation altering the C-terminal amino acids, KYFKC (K443S), which was designed to disrupt the dimerization of IE4 protein. Transfections with these mutant cosmids yielded no virus, indicating that this KYFKC motif was essential for IE4 function.

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Year:  2003        PMID： 14581575      PMCID： PMC254250          DOI： 10.1128/jvi.77.22.12369-12372.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

Review 1.  Herpes zoster in the elderly: issues related to geriatrics.

Authors:  K Schmader
Journal:  Clin Infect Dis       Date:  1999-04       Impact factor: 9.079

2.  The acidic amino-terminal region of varicella-zoster virus open reading frame 4 protein is required for transactivation and can functionally replace the corresponding region of herpes simplex virus ICP27.

Authors:  M Moriuchi; H Moriuchi; S Debrus; J Piette; J I Cohen
Journal:  Virology       Date:  1995-04-01       Impact factor: 3.616

3.  Construction of varicella-zoster virus recombinants from parent Oka cosmids and demonstration that ORF65 protein is dispensable for infection of human skin and T cells in the SCID-hu mouse model.

Authors:  Takahiro Niizuma; Leigh Zerboni; Marvin H Sommer; Hideki Ito; Stewart Hinchliffe; Ann M Arvin
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

4.  Mutational analysis of the role of glycoprotein I in varicella-zoster virus replication and its effects on glycoprotein E conformation and trafficking.

Authors:  S Mallory; M Sommer; A M Arvin
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

5.  Activation of the human immunodeficiency virus long terminal repeat by varicella-zoster virus IE4 protein requires nuclear factor-kappaB and involves both the amino-terminal and the carboxyl-terminal cysteine-rich region.

Authors:  P D de Maisieres; L Baudoux-Tebache; M P Merville; B Rentier; V Bours; J Piette
Journal:  J Biol Chem       Date:  1998-05-29       Impact factor: 5.157

6.  Identification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1.

Authors:  T M Soliman; S J Silverstein
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

7.  Gene activation by Varicella-zoster virus IE4 protein requires its dimerization and involves both the arginine-rich sequence, the central part, and the carboxyl-terminal cysteine-rich region.

Authors:  L Baudoux; P Defechereux; B Rentier; J Piette
Journal:  J Biol Chem       Date:  2000-10-20       Impact factor: 5.157

8.  Self-interaction of the herpes simplex virus type 1 regulatory protein ICP27.

Authors:  Y Zhi; K S Sciabica; R M Sandri-Goldin
Journal:  Virology       Date:  1999-05-10       Impact factor: 3.616

9.  Varicella-zoster virus open reading frame 4 encodes an immediate-early protein with posttranscriptional regulatory properties.

Authors:  P Defechereux; S Debrus; L Baudoux; B Rentier; J Piette
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

10.  Varicella-zoster virus open reading frame 4 protein is functionally distinct from and does not complement its herpes simplex virus type 1 homolog, ICP27.

Authors:  H Moriuchi; M Moriuchi; H A Smith; J I Cohen
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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  13 in total

1.  UL54-null pseudorabies virus is attenuated in mice but productively infects cells in culture.

Authors:  Jennifer A Schwartz; Elizabeth E Brittle; Ashley E Reynolds; Lynn W Enquist; Saul J Silverstein
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

2.  Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs.

Authors:  Dinesh Verma; Eun A Kim; Sankar Swaminathan
Journal:  J Virol       Date:  2013-07-31       Impact factor: 5.103

Review 3.  The varicella-zoster virus genome.

Authors:  Jeffrey I Cohen
Journal:  Curr Top Microbiol Immunol       Date:  2010       Impact factor: 4.291

4.  Varicella-zoster virus ORF4 latency-associated protein is important for establishment of latency.

Authors:  Jeffrey I Cohen; Tammy Krogmann; Jeffrey P Ross; Lesley Pesnicak; Elena A Prikhod'ko
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

5.  Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor.

Authors:  Zhen Zhang; Anca Selariu; Charles Warden; Grace Huang; Ying Huang; Oluleke Zaccheus; Tong Cheng; Ningshao Xia; Hua Zhu
Journal:  PLoS Pathog       Date:  2010-07-01       Impact factor: 6.823

6.  Development of recombinant varicella-zoster viruses expressing luciferase fusion proteins for live in vivo imaging in human skin and dorsal root ganglia xenografts.

Authors:  Stefan L Oliver; Leigh Zerboni; Marvin Sommer; Jaya Rajamani; Ann M Arvin
Journal:  J Virol Methods       Date:  2008-09-24       Impact factor: 2.014

7.  A highly efficient protocol of generating and analyzing VZV ORF deletion mutants based on a newly developed luciferase VZV BAC system.

Authors:  Zhen Zhang; Ying Huang; Hua Zhu
Journal:  J Virol Methods       Date:  2008-01-22       Impact factor: 2.014

8.  Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism.

Authors:  Lenka Sedlackova; Keith D Perkins; Joy Lengyel; Anna K Strain; Vicky L van Santen; Stephen A Rice
Journal:  J Virol       Date:  2008-05-21       Impact factor: 5.103

9.  Genetic analysis of varicella-zoster virus ORF0 to ORF4 by use of a novel luciferase bacterial artificial chromosome system.

Authors:  Zhen Zhang; Jenny Rowe; Weijia Wang; Marvin Sommer; Ann Arvin; Jennifer Moffat; Hua Zhu
Journal:  J Virol       Date:  2007-06-20       Impact factor: 5.103

10.  Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway.

Authors:  Isabelle Ote; Marielle Lebrun; Patricia Vandevenne; Sébastien Bontems; Cahora Medina-Palazon; Evelyne Manet; Jacques Piette; Catherine Sadzot-Delvaux
Journal:  PLoS One       Date:  2009-11-18       Impact factor: 3.240
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