Literature DB >> 14581550

Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses.

Sylvia Dekker1, Wendy Toussaint, George Panayotou, Ton de Wit, Pim Visser, Frank Grosveld, Dubravka Drabek.   

Abstract

The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.

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Year:  2003        PMID： 14581550      PMCID： PMC254262          DOI： 10.1128/jvi.77.22.12132-12139.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  40 in total

1.  The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions.

Authors:  X Yu; X Yuan; Z Matsuda; T H Lee; M Essex
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

2.  Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains.

Authors:  H R Hoogenboom; A D Griffiths; K S Johnson; D J Chiswell; P Hudson; G Winter
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

3.  Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice.

Authors:  L J van der Laan; C Lockey; B C Griffeth; F S Frasier; C A Wilson; D E Onions; B J Hering; Z Long; E Otto; B E Torbett; D R Salomon
Journal:  Nature       Date:  2000-09-07       Impact factor: 49.962

4.  Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly.

Authors:  A Ono; J M Orenstein; E O Freed
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

Review 5.  The generation of transgenic pigs as potential organ donors for humans.

Authors:  E Cozzi; D J White
Journal:  Nat Med       Date:  1995-09       Impact factor: 53.440

6.  Induction of immune responses and molecular cloning of the heavy chain antibody repertoire of Lama glama.

Authors:  R van der Linden; B de Geus; W Stok; W Bos; D van Wassenaar; T Verrips; L Frenken
Journal:  J Immunol Methods       Date:  2000-06-23       Impact factor: 2.303

7.  Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity.

Authors:  S Urlinger; U Baron; M Thellmann; M T Hasan; H Bujard; W Hillen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

8.  Transmission of porcine endogenous retroviruses in severe combined immunodeficient mice xenotransplanted with fetal porcine pancreatic cells.

Authors:  Y M Deng; B E Tuch; W D Rawlinson
Journal:  Transplantation       Date:  2000-10-15       Impact factor: 4.939

9.  Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells.

Authors:  F Czauderna; N Fischer; K Boller; R Kurth; R R Tönjes
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

10.  A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody.

Authors:  R P Rother; W L Fodor; J P Springhorn; C W Birks; E Setter; M S Sandrin; S P Squinto; S A Rollins
Journal:  J Exp Med       Date:  1995-11-01       Impact factor: 14.307
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  9 in total

1.  Generation of heavy-chain-only antibodies in mice.

Authors:  Rick Janssens; Sylvia Dekker; Rudi W Hendriks; George Panayotou; Alexandra van Remoortere; John Kong-a San; Frank Grosveld; Dubravka Drabek
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-02       Impact factor: 11.205

Review 2.  Single domain antibodies for the knockdown of cytosolic and nuclear proteins.

Authors:  Thomas Böldicke
Journal:  Protein Sci       Date:  2017-03-24       Impact factor: 6.725

3.  Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.

Authors:  Edward Dolk; Marcel van der Vaart; David Lutje Hulsik; Gert Vriend; Hans de Haard; Silvia Spinelli; Christian Cambillau; Leon Frenken; Theo Verrips
Journal:  Appl Environ Microbiol       Date:  2005-01       Impact factor: 4.792

4.  Regulation of porcine endogenous retrovirus release by porcine and human tetherins.

Authors:  Giada Mattiuzzo; Sabrina Ivol; Yasuhiro Takeuchi
Journal:  J Virol       Date:  2009-12-16       Impact factor: 5.103

5.  Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

Authors:  Erik Engelen; Roel C Janssens; Kazuhiro Yagita; Veronique A J Smits; Gijsbertus T J van der Horst; Filippo Tamanini
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

6.  Ricin detection using phage displayed single domain antibodies.

Authors:  Ellen R Goldman; Jinny L Liu; Rachael D Bernstein; Marla D Swain; Stanley Q Mitchell; George P Anderson
Journal:  Sensors (Basel)       Date:  2009-01-19       Impact factor: 3.576

Review 7.  Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.

Authors:  Congcong Zhang; Rina M Ötjengerdes; Julian Roewe; Rebeca Mejias; Andrea L J Marschall
Journal:  BioDrugs       Date:  2020-08       Impact factor: 5.807

Review 8.  Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

Authors:  Janusz Wesolowski; Vanina Alzogaray; Jan Reyelt; Mandy Unger; Karla Juarez; Mariela Urrutia; Ana Cauerhff; Welbeck Danquah; Björn Rissiek; Felix Scheuplein; Nicole Schwarz; Sahil Adriouch; Olivier Boyer; Michel Seman; Alexei Licea; David V Serreze; Fernando A Goldbaum; Friedrich Haag; Friedrich Koch-Nolte
Journal:  Med Microbiol Immunol       Date:  2009-06-16       Impact factor: 3.402

Review 9.  Porcine Endogenous Retrovirus (PERV) - Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells.

Authors:  Krzysztof Łopata; Emilia Wojdas; Roman Nowak; Paweł Łopata; Urszula Mazurek
Journal:  Front Microbiol       Date:  2018-04-11       Impact factor: 5.640
  9 in total

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