BACKGROUND: Diet has been recognised as having a role in the aetiology of oral and pharyngeal cancer, and dietary factors may account for 10-15% of cases in Europe. Folate deficiency has been linked to risk of several cancers, but has not been studied adequately with respect to oral cancer. PATIENTS AND METHODS: This case-control study, conducted in Italy and French-speaking Switzerland, included 749 patients with incident cancer of the oral cavity and pharynx, and 1772 hospital controls with acute, non-neoplastic conditions. The interviews used a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multiple logistic regression. RESULTS: The ORs were 0.68 (95% CI 0.52-0.88) for the intermediate tertile and 0.53 (95% CI 0.40-0.69) for the highest tertile of dietary folate intake, compared with the lowest tertile. No heterogeneity was found in strata of gender, age, methionine intake or alcohol consumption. The combined OR for low-folate and high-alcohol intake versus high-folate and low-alcohol intake was 22.3 (95% CI 13.1-38). CONCLUSIONS: Our study supports a protective role of folate against oral and pharyngeal carcinogenesis. Compared with low folate intake, a consistent reduction in risk was already observed from intermediate levels of intake, suggesting that cancer risk may be related to relative folate deficiency.
BACKGROUND: Diet has been recognised as having a role in the aetiology of oral and pharyngeal cancer, and dietary factors may account for 10-15% of cases in Europe. Folate deficiency has been linked to risk of several cancers, but has not been studied adequately with respect to oral cancer. PATIENTS AND METHODS: This case-control study, conducted in Italy and French-speaking Switzerland, included 749 patients with incident cancer of the oral cavity and pharynx, and 1772 hospital controls with acute, non-neoplastic conditions. The interviews used a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multiple logistic regression. RESULTS: The ORs were 0.68 (95% CI 0.52-0.88) for the intermediate tertile and 0.53 (95% CI 0.40-0.69) for the highest tertile of dietary folate intake, compared with the lowest tertile. No heterogeneity was found in strata of gender, age, methionine intake or alcohol consumption. The combined OR for low-folate and high-alcohol intake versus high-folate and low-alcohol intake was 22.3 (95% CI 13.1-38). CONCLUSIONS: Our study supports a protective role of folate against oral and pharyngeal carcinogenesis. Compared with low folate intake, a consistent reduction in risk was already observed from intermediate levels of intake, suggesting that cancer risk may be related to relative folate deficiency.
Authors: Anna E Arthur; Sonia A Duffy; Gloria I Sanchez; Stephen B Gruber; Jeffrey E Terrell; James R Hebert; Emily Light; Carol R Bradford; Nisha J D'Silva; Thomas E Carey; Gregory T Wolf; Karen E Peterson; Laura S Rozek Journal: Nutr Cancer Date: 2011-06-11 Impact factor: 2.900
Authors: Jayapriyaa R Shanmugham; Athanasios I Zavras; Bernard A Rosner; Edward L Giovannucci Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-09-14 Impact factor: 4.254
Authors: Carlotta Galeone; Valeria Edefonti; Maria Parpinel; Emanuele Leoncini; Keitaro Matsuo; Renato Talamini; Andrew F Olshan; Jose P Zevallos; Deborah M Winn; Vijayvel Jayaprakash; Kirsten Moysich; Zuo-Feng Zhang; Hal Morgenstern; Fabio Levi; Cristina Bosetti; Karl Kelsey; Michael McClean; Stimson Schantz; Guo-Pei Yu; Paolo Boffetta; Yuan-Chin Amy Lee; Mia Hashibe; Carlo La Vecchia; Stefania Boccia Journal: Int J Cancer Date: 2014-07-07 Impact factor: 7.396
Authors: Justin A Colacino; Anna E Arthur; Dana C Dolinoy; Maureen A Sartor; Sonia A Duffy; Douglas B Chepeha; Carol R Bradford; Heather M Walline; Jonathan B McHugh; Nisha D'Silva; Thomas E Carey; Gregory T Wolf; Jeremy M G Taylor; Karen E Peterson; Laura S Rozek Journal: Epigenetics Date: 2012-06-22 Impact factor: 4.528