| Literature DB >> 14580911 |
M J Dalby1, D Giannaras, M O Riehle, N Gadegaard, S Affrossman, A S G Curtis.
Abstract
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical method of producing nano-topography. This manuscript investigates human fibroblast response to 27nm high nano-islands produced by polymer demixing. Cell spreading, cytoskeleton, focal adhesion and Rac localisation were studied. The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture.Entities:
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Year: 2004 PMID： 14580911 DOI： 10.1016/s0142-9612(03)00475-7
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479