| Literature DB >> 14580859 |
G Rose1, S Dato, K Altomare, D Bellizzi, S Garasto, V Greco, G Passarino, E Feraco, V Mari, C Barbi, M BonaFe, C Franceschi, Q Tan, S Boiko, A I Yashin, G De Benedictis.
Abstract
The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.Entities:
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Year: 2003 PMID： 14580859 DOI： 10.1016/s0531-5565(03)00209-2
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032