Utility and evaluation of biochemical markers of alcohol consumption.

Biochemical markers of alcohol consumption have a variety of clinical and research applications. Currently available markers such as the serum gamma-glutamyl transpeptidase (GGT), serum transaminases, and the mean corpuscular volume (MCV) lack sufficient sensitivity and specificity to be used for screening of alcoholism in ambulatory patients. However, these tests can be helpful in corroborating a clinical suspicion of alcoholism. A number of special laboratory markers of alcoholism recently have been developed which may have increased diagnostic accuracy. Promising potential markers include serum carbohydrate-deficient transferrin (CDT), red blood cell acetaldehyde, and acetaldehyde adducts. The application of reliable and practical markers of alcohol consumption could lead to significant improvements in the treatment of alcoholism and in the assessment of clinical trials.