Literature DB >> 14580106

The effect of fluconazole treatment on tumor necrosis factor-alpha production in murine candidiasis.

Ayse Kalkanci1, Semra Kustimur.   

Abstract

That systemic candidiasis increases TNF-alpha has been proved in various studies. In our study, we investigated if fluconazole too, which is used in treatment, has an additional effect on the increase of TNF-alpha. On the sixth day of the experimental infection, it was measured that TNF-alpha levels of candidiasis was 699 +/- 60 pg/ml whereas it was 683 +/- 35 pg/ml in the mice that were treated with fluconazole. TNF-alpha levels were measured by enzyme-linked immunosorbant assay. Due to the fact that no statistically significant difference was found between them (p > .05) it was thought that fluconazole did not have an additional effect on the increase of TNF-alpha in candidiasis.

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Year:  2002        PMID： 14580106      PMCID： PMC2588809     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  10 in total

1.  Variation in fluconazole efficacy for Candida albicans strains sequentially isolated from oral cavities of patients with AIDS in an experimental murine candidiasis model.

Authors:  F Barchiesi; L K Najvar; M F Luther; G Scalise; M G Rinaldi; J R Graybill
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

Review 2.  Macrophages in resistance to candidiasis.

Authors:  A Vázquez-Torres; E Balish
Journal:  Microbiol Mol Biol Rev       Date:  1997-06       Impact factor: 11.056

3.  Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages.

Authors:  M Yamada; A Tanimoto; G Ichinowatari; H Yaginuma; K Ohuchi
Journal:  Eur J Pharmacol       Date:  1999-06-25       Impact factor: 4.432

4.  A new azole derivative of 1,4-benzothiazine increases the antifungal mechanisms of natural effector cells.

Authors:  L Pitzurra; R Fringuelli; S Perito; F Schiaffella; R Barluzzi; F Bistoni; A Vecchiarelli
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

5.  Effects of cytokines and fluconazole on the activity of human monocytes against Candida albicans.

Authors:  A L Baltch; R P Smith; M A Franke; W J Ritz; P B Michelsen; L H Bopp
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

Review 6.  Current and emerging azole antifungal agents.

Authors:  D J Sheehan; C A Hitchcock; C M Sibley
Journal:  Clin Microbiol Rev       Date:  1999-01       Impact factor: 26.132

Review 7.  Immunomodulating activity of antifungal drugs.

Authors:  H Yamaguchi; S Abe; Y Tokuda
Journal:  Ann N Y Acad Sci       Date:  1993-06-23       Impact factor: 5.691

8.  Tumor necrosis factor-alpha and interleukin-1 beta in cerebrospinal fluid of patients with coccidioidal meningitis during therapy with fluconazole. National Institute of Allergy and Infectious Diseases Mycoses Study Group.

Authors:  N M Ampel; D R Ahmann; K L Delgado; J N Galgiani; G A Cloud
Journal:  J Infect Dis       Date:  1995-06       Impact factor: 5.226

9.  Comparative capacity of four antifungal agents to stimulate murine macrophages to produce tumour necrosis factor alpha: an effect that is attenuated by pentoxifylline, liposomal vesicles, and dexamethasone.

Authors:  A Louie; A L Baltch; M A Franke; R P Smith; M A Gordon
Journal:  J Antimicrob Chemother       Date:  1994-12       Impact factor: 5.790

10.  Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis.

Authors:  A Louie; A L Baltch; R P Smith; M A Franke; W J Ritz; J K Singh; M A Gordon
Journal:  Infect Immun       Date:  1994-07       Impact factor: 3.441
  10 in total
  1 in total

1.  Impact of different antimycotics on cytokine levels in an in vitro aspergillosis model in human whole blood.

Authors:  Zoe Oesterreicher; Sabine Eberl; Markus Zeitlinger
Journal:  Infection       Date:  2019-08-01       Impact factor: 3.553
  1 in total

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