Literature DB >> 14579457

[Sleeping sickness, forgotten illness: what are the consequences in the field?].

P P Simarro1, F J Louis, J Jannin.   

Abstract

For nearly 25 years, sleeping sickness was forgotten and increasingly neglected. Research programs and control activities against human African trypanosomiasis were discontinued. Statistical studies show a constant decrease in the number of people screened and cases detected and little change in the ratios of actively versus passively diagnosed cases and of the early (blood and lymph involvement) versus late (cerebral involvement) stage cases. In the field neglect of the disease led to deterioration not only physical facilities but also human resources. As teams aged, senior members were often replaced by less than fully qualified people resulting in a decline in efficiency and organization. Many basic notions were lost and the albeit scarce innovations in diagnosis and therapy were often overlooked. When the fight against sleeping sickness was finally resumed, these factors had to be taken into account. Efforts in the field have been focused on four areas: renovation of equipment, didactic and practical training for health care personnel, development of a decision-making algorithm based on diagnostic findings, and implementation of new therapeutic protocols.

Entities:  

Mesh:

Year:  2003        PMID: 14579457

Source DB:  PubMed          Journal:  Med Trop (Mars)        ISSN: 0025-682X


  5 in total

Review 1.  Options for field diagnosis of human african trypanosomiasis.

Authors:  François Chappuis; Louis Loutan; Pere Simarro; Veerle Lejon; Philippe Büscher
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

Review 2.  Improving Sterile Insect Technique (SIT) for tsetse flies through research on their symbionts and pathogens.

Authors:  Adly M M Abd-Alla; Max Bergoin; Andrew G Parker; Nguya K Maniania; Just M Vlak; Kostas Bourtzis; Drion G Boucias; Serap Aksoy
Journal:  J Invertebr Pathol       Date:  2012-07-24       Impact factor: 2.841

3.  Human African trypanosomiasis research gets a boost: unraveling the tsetse genome.

Authors:  Serap Aksoy; Geoffrey Attardo; Matt Berriman; Alan Christoffels; Mike Lehane; Dan Masiga; Yeya Toure
Journal:  PLoS Negl Trop Dis       Date:  2014-04-24

4.  Midgut expression of immune-related genes in Glossina palpalis gambiensis challenged with Trypanosoma brucei gambiense.

Authors:  Illiassou Hamidou Soumana; Bernadette Tchicaya; Paul Chuchana; Anne Geiger
Journal:  Front Microbiol       Date:  2014-11-10       Impact factor: 5.640

5.  Prevalence of salivary gland hypertrophy syndrome in laboratory colonies and wild flies of Glossina pallidipes in Ethiopia.

Authors:  Mahder M Yimer; Dereje G Bula; Tsegabirhan K Tesama; Kassaw A Tadesse; Birhanu H Abera
Journal:  Onderstepoort J Vet Res       Date:  2015-06-01       Impact factor: 1.792

  5 in total

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