| Literature DB >> 14579124 |
Curt R Freed1, Maureen A Leehey, Michael Zawada, Kimberly Bjugstad, Laetitia Thompson, Robert E Breeze.
Abstract
Embryonic dopamine cell transplants survive in nearly all patients regardless of age and without immunosuppression. Transplants can improve Parkinson "off" symptoms up to the best effects of L-dopa observed preoperatively. They cannot improve the "best on" state. Transplants appear to survive indefinitely. In 10 to 15% of patients, transplants can reproduce the dyskinetic effects of L-dopa even after discontinuing all L-dopa. Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment.Entities:
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Year: 2003 PMID： 14579124 DOI： 10.1007/s00415-003-1308-5
Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849