Literature DB >> 14578629

Intravenous administration of nifekalant hydrochloride for the prevention of ischemia-induced ventricular tachyarrhythmia in patients with renal failure undergoing hemodialysis.

Masafumi Myoishi1, Satoshi Yasuda, Shunichi Miyazaki, Kazuyuki Ueno, Isao Morii, Kazuhiro Satomi, Yoritaka Otsuka, Atsushi Kawamura, Takashi Kurita, Shiro Kamakura, Hiroshi Nonogi.   

Abstract

Excretion in the urine is an important pathway for the elimination of nifekalant hydrochloride (NIF), a novel class III antiarrhythmic agent. Three patients with renal failure were undergoing hemodialysis and receiving NIF for the prevention of ischemia-induced ventricular tachyarrhythmia. Because NIF is not dialyzed, dose adjustment at relatively low concentrations was required, with monitoring of the QT interval.

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Year:  2003        PMID: 14578629     DOI: 10.1253/circj.67.898

Source DB:  PubMed          Journal:  Circ J        ISSN: 1346-9843            Impact factor:   2.993


  2 in total

1.  Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias.

Authors:  Ioannis N Pantazopoulos; Georgios T Troupis; Charalampos N Pantazopoulos; Theodoros T Xanthos
Journal:  World J Cardiol       Date:  2011-06-26

2.  Negative lusitropic property of nifekalant identified using ventricular pressure-volume loop analyses in anesthetized monkeys.

Authors:  Tomomichi Ishizaka; Yu Yoshimatsu; Yu Maeda; Katsuyoshi Chiba; Kazuhiko Mori
Journal:  Exp Anim       Date:  2018-10-17
  2 in total

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