Literature DB >> 14576857

The MRP family of drug efflux pumps.

Gary D Kruh1, Martin G Belinsky.   

Abstract

The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs, but also into factors that influence drug distribution in the body, membrane systems that are involved in the extrusion of reduced folates, cysteinyl leukotrienes and bile acids, and the molecular basis of two hereditary conditions in humans. The review will describe the biochemical properties, drug resistance activities and potential in vivo functions of these unusual pumps.

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Year:  2003        PMID： 14576857     DOI： 10.1038/sj.onc.1206953

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  158 in total

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Authors:  Rongbao Zhao; Larry H Matherly; I David Goldman
Journal:  Expert Rev Mol Med       Date:  2009-01-28       Impact factor: 5.600

Review 5.  Multidrug resistance-associated proteins 3, 4, and 5.

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7.  Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.

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8.  Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.

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Journal:  Biochem J       Date:  2007-08-15       Impact factor: 3.857

Review 9.  Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases.

Authors:  V L Kinnula
Journal:  Thorax       Date:  2005-08       Impact factor: 9.139

10.  Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance.

Authors:  Marek Kucka; Karla Kretschmannova; Takayo Murano; Chung-Pu Wu; Hana Zemkova; Suresh V Ambudkar; Stanko S Stojilkovic
Journal:  Mol Pharmacol       Date:  2009-11-10       Impact factor: 4.436
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