Literature DB >> 14576142

Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate.

Marylore Chenel1, Anne Limosin, Sandrine Marchand, Joël Paquereau, Olivier Mimoz, William Couet.   

Abstract

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistently observed without glutamate level modifications. Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14576142      PMCID： PMC253770          DOI： 10.1128/AAC.47.11.3660-3662.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.

Authors:  K Akahane; M Sekiguchi; T Une; Y Osada
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

2.  Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine.

Authors:  B Moghaddam; B S Bunney
Journal:  J Neurochem       Date:  1989-08       Impact factor: 5.372

3.  Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus.

Authors:  Yuto Ueda; Hidekatsu Yokoyama; Akira Nakajima; Jun Tokumaru; Taku Doi; Yoshio Mitsuyama
Journal:  Exp Brain Res       Date:  2002-09-25       Impact factor: 1.972

4.  Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats.

Authors:  I Smolders; C Gousseau; S Marchand; W Couet; G Ebinger; Y Michotte
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

5.  Central nervous system toxicity of quinolones: human and animal findings.

Authors:  W Christ
Journal:  J Antimicrob Chemother       Date:  1990-10       Impact factor: 5.790

6.  Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.

Authors:  A Delon; F Huguet; P Courtois; J M Vierfond; S Bouquet; W Couet
Journal:  J Pharmacol Exp Ther       Date:  1997-02       Impact factor: 4.030

Review 7.  Antibiotic-induced convulsions.

Authors:  K L Wallace
Journal:  Crit Care Clin       Date:  1997-10       Impact factor: 3.598

8.  Decreased GABA release following tonic-clonic seizures is associated with an increase in extracellular glutamate in rat hippocampus in vivo.

Authors:  H L Rowley; K F Martin; C A Marsden
Journal:  Neuroscience       Date:  1995-09       Impact factor: 3.590

9.  Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.

Authors:  Marylore Chenel; Agnès Barbot; Antoine Dupuis; Olivier Mimoz; Joël Paquereau; Serge Bouquet; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2003-06       Impact factor: 5.191

10.  Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

Authors:  A Tsuji; H Sato; Y Kume; I Tamai; E Okezaki; O Nagata; H Kato
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.