Literature DB >> 14575912

A meta-analysis of whole genome linkage screens in multiple sclerosis.

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Abstract

Linkage studies in complex diseases like multiple sclerosis, where the effects attributable to individual loci are modest, are critically dependent upon the number of families included. We have combined the raw genotyping data from all published genome linkage screens in multiple sclerosis and thereby performed a linkage analysis including 719 families studied with a weighted average of 359 microsatellite markers per family (range 257-453) providing an average marker separation of 10.2 cM. Linkage with genome-wide significance is confirmed in the HLA region on chromosome 6p21. In addition, two novel regions suggestive of linkage are seen (17q21 and 22q13). Our simulations would imply that the number of peaks with NPL scores >/=2.1 exceeds the number expected by chance alone.

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Year:  2003        PMID： 14575912     DOI： 10.1016/j.jneuroim.2003.08.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  24 in total

1.  Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland.

Authors:  Christopher McGuigan; Ciaran Dunne; John Crowley; Richard Hagan; Genevieve Rooney; Eimear Lawlor; Michael Hutchinson
Journal:  J Neurol       Date:  2005-09-16       Impact factor: 4.849

2.  A high-density screen for linkage in multiple sclerosis.

Authors:  Stephen Sawcer; Maria Ban; Mel Maranian; Tai Wai Yeo; Alastair Compston; Andrew Kirby; Mark J Daly; Philip L De Jager; Emily Walsh; Eric S Lander; John D Rioux; David A Hafler; Adrian Ivinson; Jacqueline Rimmler; Simon G Gregory; Silke Schmidt; Margaret A Pericak-Vance; Eva Akesson; Jan Hillert; Pameli Datta; Annette Oturai; Lars P Ryder; Hanne F Harbo; Anne Spurkland; Kjell-Morten Myhr; Mikko Laaksonen; David Booth; Robert Heard; Graeme Stewart; Robin Lincoln; Lisa F Barcellos; Stephen L Hauser; Jorge R Oksenberg; Shannon J Kenealy; Jonathan L Haines
Journal:  Am J Hum Genet       Date:  2005-07-29       Impact factor: 11.025

3.  Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.

Authors:  Dan Nicolae; Nancy J Cox; Lucille A Lester; Daniel Schneider; Zheng Tan; Christine Billstrand; Susan Kuldanek; Joseph Donfack; Paul Kogut; Nina M Patel; Jeffrey Goodenbour; Timothy Howard; Raoul Wolf; Gerard H Koppelman; Steven R White; Rodney Parry; Dirkje S Postma; Deborah Meyers; Eugene R Bleecker; Joan S Hunt; Julian Solway; Carole Ober
Journal:  Am J Hum Genet       Date:  2004-12-20       Impact factor: 11.025

4.  Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice.

Authors:  Johan Ockinger; Pablo Serrano-Fernández; Steffen Möller; Saleh M Ibrahim; Tomas Olsson; Maja Jagodic
Journal:  Genetics       Date:  2006-04-19       Impact factor: 4.562

5.  The genetic aspects of multiple sclerosis.

Authors:  Stephen Sawcer
Journal:  Ann Indian Acad Neurol       Date:  2009-10       Impact factor: 1.383

6.  Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips.

Authors:  René Gödde; Klaus Rohde; Christian Becker; Mahammad R Toliat; Patricia Entz; Anita Suk; Norbert Müller; Eckhart Sindern; Michael Haupts; Sebastian Schimrigk; Peter Nürnberg; Jörg T Epplen
Journal:  J Mol Med (Berl)       Date:  2005-03-16       Impact factor: 4.599

7.  A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Authors:  Tai Wai Yeo; Philip L De Jager; Simon G Gregory; Lisa F Barcellos; Amie Walton; An Goris; Chiara Fenoglio; Maria Ban; Craig J Taylor; Reyna S Goodman; Emily Walsh; Cara S Wolfish; Roger Horton; James Traherne; Stephan Beck; John Trowsdale; Stacy J Caillier; Adrian J Ivinson; Todd Green; Susan Pobywajlo; Eric S Lander; Margaret A Pericak-Vance; Jonathan L Haines; Mark J Daly; Jorge R Oksenberg; Stephen L Hauser; Alastair Compston; David A Hafler; John D Rioux; Stephen Sawcer
Journal:  Ann Neurol       Date:  2007-03       Impact factor: 10.422

Review 8.  A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches.

Authors:  V V Bashinskaya; O G Kulakova; A N Boyko; A V Favorov; O O Favorova
Journal:  Hum Genet       Date:  2015-09-25       Impact factor: 4.132

9.  Gene expression studies in multiple sclerosis.

Authors:  Lotti Tajouri; Francesca Fernandez; Lyn R Griffiths
Journal:  Curr Genomics       Date:  2007-05       Impact factor: 2.236

10.  Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.

Authors:  Roberta Pastorino; Cristina Menni; Monserrata Barca; Luisa Foco; Valeria Saddi; Giovanna Gazzaniga; Raffaela Ferrai; Luca Mascaretti; Frank Dudbridge; Carlo Berzuini; Salvatore Bruno Murgia; Maria Luisa Piras; Anna Ticca; Pier Paolo Bitti; Luisa Bernardinelli
Journal:  PLoS One       Date:  2009-08-05       Impact factor: 3.240
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