Literature DB >> 14575477

Total synthesis of wedelolactone.

Chuang Chuang Li1, Zhi Xiang Xie, Yan Dong Zhang, Jia Hua Chen, Zhen Yang.   

Abstract

The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction. This approach allows access to diversified analogues of wedelolactone.

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Year:  2003        PMID： 14575477     DOI： 10.1021/jo030228f

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  10 in total

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Journal:  Bioorg Med Chem Lett       Date:  2017-07-11       Impact factor: 2.823

2.  Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects.

Authors:  Leah K Forsberg; Mercy Anyika; Zhenyuan You; Sean Emery; Mason McMullen; Rick T Dobrowsky; Brian S J Blagg
Journal:  Eur J Med Chem       Date:  2017-10-18       Impact factor: 6.514

3.  One-pot two-step synthesis of 3-iodo-4-aryloxy coumarins and their Pd/C-catalyzed annulation to coumestans.

Authors:  Niranjan Panda; Irshad Mattan
Journal:  RSC Adv       Date:  2018-02-16       Impact factor: 4.036

4.  Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1.

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Journal:  Tetrahedron       Date:  2016-06-09       Impact factor: 2.457

5.  Total synthesis of psoralidin, an anticancer natural product.

Authors:  Pallab Pahari; Jürgen Rohr
Journal:  J Org Chem       Date:  2009-04-03       Impact factor: 4.354

6.  Selective syntheses of leuconolam, leuconoxine, and mersicarpine alkaloids from a common intermediate through regiocontrolled cyclizations by Staudinger reactions†Electronic supplementary information (ESI) available: Experimental details and procedures, compound characterization data, copies of 1H and 13C NMR spectra for new compounds. See DOI: 10.1039/c4qo00312hClick here for additional data file.

Authors:  Zining Li; Qian Geng; Zhe Lv; Beau P Pritchett; Katsuaki Baba; Yoshitaka Numajiri; Brian M Stoltz; Guangxin Liang
Journal:  Org Chem Front       Date:  2015-01-27       Impact factor: 5.281

7.  Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor.

Authors:  Huidan Huang; Jianqiu Chen; Jie Ren; Chaofeng Zhang; Fei Ji
Journal:  Molecules       Date:  2019-11-15       Impact factor: 4.411

8.  Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy.

Authors:  Peter Smoak; Susan J Burke; J Jason Collier
Journal:  SN Compr Clin Med       Date:  2021-08-15

9.  Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2'-hydroxyl-3-arylcoumarins.

Authors:  Xianheng Song; Xiang Luo; Jianfei Sheng; Jianheng Li; Zefeng Zhu; Zhibo Du; Hui Miao; Meng Yan; Mingkang Li; Yong Zou
Journal:  RSC Adv       Date:  2019-06-03       Impact factor: 4.036

10.  5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety.

Authors:  Hamid Nadri; Morteza Pirali-Hamedani; Alireza Moradi; Amirhossein Sakhteman; Alireza Vahidi; Vahid Sheibani; Ali Asadipour; Nouraddin Hosseinzadeh; Mohammad Abdollahi; Abbas Shafiee; Alireza Foroumadi
Journal:  Daru       Date:  2013-02-27       Impact factor: 3.117
  10 in total

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