| Literature DB >> 14575429 |
Courtney M Starks1, Yiqing Zhou, Fenghua Liu, Peter J Licari.
Abstract
Nine new epothilone analogues (6-8, 10, 11a, 11b, 12, 13, and 15) were isolated from fermentations of Myxococcus xanthus strains engineered with modified polyketide synthase genes. The epothilone structures were elucidated primarily through interpretation of 1D and 2D NMR data. 4-Desmethyl-10,11-didehydroepothilone D (6) displayed activity against several tumor cell lines, including a multi-drug-resistant cell line.Entities:
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Year: 2003 PMID： 14575429 DOI： 10.1021/np030218+
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050