Literature DB >> 14575306

Functional and structural characterization of anti-beta1-adrenoceptor autoantibodies of spontaneously hypertensive rats.

Gerd Wallukat1, Svenia Podlowski, Eberhard Nissen, Rosemarie Morwinski, Csaba Csonka, Arpad Tosaki, Ingolf E Blasig.   

Abstract

Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the beta1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the beta1-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the beta1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-beta1-adrenoceptor antibodies in the induction of human cardiomyopathy.

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Year:  2003        PMID： 14575306

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  42 in total

1.  Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes.

Authors:  T Christ; E Wettwer; D Dobrev; E Adolph; M Knaut; G Wallukat; U Ravens
Journal:  J Mol Cell Cardiol       Date:  2001-08       Impact factor: 5.000

2.  Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

Authors:  M R Bristow; R Ginsburg; V Umans; M Fowler; W Minobe; R Rasmussen; P Zera; R Menlove; P Shah; S Jamieson
Journal:  Circ Res       Date:  1986-09       Impact factor: 17.367

3.  Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits.

Authors:  S Matsui; M Persson; H M Fu; M Hayase; S Katsuda; K Teraoka; T Kurihara; M L Fu
Journal:  Herz       Date:  2000-05       Impact factor: 1.443

4.  From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonists.

Authors:  A Mijares; D Lebesgue; G Wallukat; J Hoebeke
Journal:  Mol Pharmacol       Date:  2000-08       Impact factor: 4.436

5.  Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease.

Authors:  R Elies; I Ferrari; G Wallukat; D Lebesgue; P Chiale; M Elizari; M Rosenbaum; J Hoebeke; M J Levin
Journal:  J Immunol       Date:  1996-11-01       Impact factor: 5.422

6.  Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.

Authors:  C J Limas; I F Goldenberg; C Limas
Journal:  Circ Res       Date:  1989-01       Impact factor: 17.367

7.  The spontaneously hypertensive rat as a model of the transition from compensated left ventricular hypertrophy to failure.

Authors:  O H Bing; W W Brooks; K G Robinson; M T Slawsky; J A Hayes; S E Litwin; S Sen; C H Conrad
Journal:  J Mol Cell Cardiol       Date:  1995-01       Impact factor: 5.000

8.  Antibodies to beta 1 and beta 2 adrenoreceptors in Chagas' disease.

Authors:  L Sterin-Borda; C Perez Leiros; M Wald; G Cremaschi; E Borda
Journal:  Clin Exp Immunol       Date:  1988-12       Impact factor: 4.330

9.  Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops.

Authors:  G Wallukat; A Wollenberger; R Morwinski; H F Pitschner
Journal:  J Mol Cell Cardiol       Date:  1995-01       Impact factor: 5.000

10.  Diminished cardiac hypertrophy and muscle performance in older compared with younger adult rats with chronic atrioventricular block.

Authors:  G D Walford; H A Spurgeon; E G Lakatta
Journal:  Circ Res       Date:  1988-09       Impact factor: 17.367
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  5 in total

Review 1.  Chronic Chagas' heart disease: a disease on its way to becoming a worldwide health problem: epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine.

Authors:  Silvia Gilka Muñoz-Saravia; Annekathrin Haberland; Gerd Wallukat; Ingolf Schimke
Journal:  Heart Fail Rev       Date:  2012-01       Impact factor: 4.214

2.  Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats.

Authors:  Katrin Wenzel; Gerd Wallukat; Fatimunnisa Qadri; Norbert Hubner; Herbert Schulz; Oliver Hummel; Florian Herse; Arnd Heuser; Robert Fischer; Harald Heidecke; Friedrich C Luft; Dominik N Muller; Rainer Dietz; Ralf Dechend
Journal:  PLoS One       Date:  2010-02-24       Impact factor: 3.240

Review 3.  Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond.

Authors:  Yang Xia; Rodney E Kellems
Journal:  Circ Res       Date:  2013-06-21       Impact factor: 17.367

4.  Autoantibodies targeting AT1 receptor from patients with acute coronary syndrome upregulate proinflammatory cytokines expression in endothelial cells involving NF-κB pathway.

Authors:  Weijuan Li; Zhi Li; Yaoqi Chen; Songhai Li; Yuanyuan Lv; Wenping Zhou; Mengyang Liao; Feng Zhu; Zihua Zhou; Xiang Cheng; Qiutang Zeng; Yuhua Liao; Yumiao Wei
Journal:  J Immunol Res       Date:  2014-11-30       Impact factor: 4.818

5.  Suppression of β1-Adrenoceptor Autoantibodies is Involved in the Antiarrhythmic Effects of Omega-3 Fatty Acids in Male and Female Hypertensive Rats.

Authors:  Barbara Szeiffova Bacova; Jana Radosinska; Gerd Wallukat; Miroslav Barancik; Anne Wallukat; Vladimir Knezl; Matus Sykora; Ludovit Paulis; Narcis Tribulova
Journal:  Int J Mol Sci       Date:  2020-01-14       Impact factor: 5.923
  5 in total

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