Impaired fertility caused by endocrine dysfunction in women.

Infertility can be frustrating for patients and physicians. Endocrine dysfunction can impair fertility and alter pregnancy outcome. Once the diagnosis is secured, most endocrine disorders are reversible or can be adequately managed to restore fertility and decrease associated pregnancy complications. Improved understanding of the subtleties and intricacies of mechanisms by which endocrinopathies can hinder fertility and influence the course of a pregnancy is vital, more so in the era of assisted reproductive technology, because pregnancy in an abnormal endocrine environment can be disastrous. The role of autoimmunity in infertility and pregnancy loss is less clear; in this context, there are limited management options to improve fertility and overall pregnancy outcomes.