Literature DB >> 14573796

Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows.

Giuseppe Borzacchiello1, Giuseppe Iovane1, Maria Luisa Marcante2, Federica Poggiali2, Franco Roperto1, Sante Roperto1, Aldo Venuti2.   

Abstract

Samples of neoplastic and normal urothelium were obtained from cows originating from areas of southern Italy, a region in which chronic enzootic haematuria is endemic and bracken fern infestation is widespread. Specimens were analysed for bovine papillomavirus type 2 (BPV-2) DNA, BPV-2 E5 expression and telomerase activity. A total of 46 of 60 tumours and 17 of 34 normal bladder mucosa samples harboured BPV-2 DNA. Analysis of a subset of samples showed E5 protein expression and telomerase activity in tumour tissue only. No normal samples positive for BPV DNA showed E5 protein expression or telomerase activity, suggesting the presence of DNA in a latent state. Taken together, these data on naturally occurring bovine bladder tumours corroborate the hypothesis of their virus origin.

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Year:  2003        PMID： 14573796     DOI： 10.1099/vir.0.19412-0

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  16 in total

1.  Pathological study of non-neoplastic urinary bladder lesions in cattle and buffaloes: a preliminary report.

Authors:  Ramesh Somvanshi; Sonia Pathania; Nagappan Nagarajan; Kanchan Pangty; Pawan Kumar
Journal:  Trop Anim Health Prod       Date:  2011-09-21       Impact factor: 1.559

2.  Detection and phylogenetic analysis of bovine papillomavirus in cutaneous warts in cattle in Tamaulipas, Mexico.

Authors:  Edith Rojas-Anaya; Antonio Cantú-Covarrubias; José Francisco Morales Álvarez; Elizabeth Loza-Rubio
Journal:  Can J Vet Res       Date:  2016-10       Impact factor: 1.310

3.  Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder.

Authors:  Mariarita Romanucci; Daniela Malatesta; Andrea Ciccarelli; Laura Bongiovanni; Chiara Palmieri; Giuseppe Borzacchiello; Franco Roperto; Gennaro Altamura; Leonardo Della Salda
Journal:  Cell Stress Chaperones       Date:  2012-05-02       Impact factor: 3.667

4.  Detection and quantification of bovine papillomavirus DNA by digital droplet PCR in sheep blood.

Authors:  Sante Roperto; Anna Cutarelli; Federica Corrado; Francesca De Falco; Canio Buonavoglia
Journal:  Sci Rep       Date:  2021-05-13       Impact factor: 4.379

5.  Detection and Quantification of the E6 Oncogene in Bovine Papillomavirus Types 2 and 13 From Urinary Bladder Lesions of Cattle.

Authors:  Brígida Kussumoto de Alcântara; Michele Lunardi; Alais Maria Dall Agnol; Alice Fernandes Alfieri; Amauri Alcindo Alfieri
Journal:  Front Vet Sci       Date:  2021-05-14

6.  Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors.

Authors:  Sante Roperto; Giuseppe Borzacchiello; Iolanda Esposito; Marita Riccardi; Chiara Urraro; Roberta Lucà; Annunziata Corteggio; Rosarita Tatè; Michele Cermola; Orlando Paciello; Franco Roperto
Journal:  PLoS One       Date:  2012-03-27       Impact factor: 3.240

7.  Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?

Authors:  Annunziata Corteggio; Gennaro Altamura; Franco Roperto; Giuseppe Borzacchiello
Journal:  Infect Agent Cancer       Date:  2013-01-09       Impact factor: 2.965

8.  Bovine papillomavirus type 2 infection and microscopic patterns of urothelial tumors of the urinary bladder in water buffaloes.

Authors:  Paola Maiolino; Ayhan Ozkul; Aylin Sepici-Dincel; Franco Roperto; Gözde Yücel; Valeria Russo; Chiara Urraro; Roberta Lucà; Marita Georgia Riccardi; Manuela Martano; Giuseppe Borzacchiello; Iolanda Esposito; Sante Roperto
Journal:  Biomed Res Int       Date:  2013-05-22       Impact factor: 3.411

9.  Bovine papillomavirus type 2 infection and a series of mesenchymal tumors of the urinary bladder in cattle.

Authors:  Manuela Martano; Franco Roperto; Rita de Cassia Stocco; Valeria Russo; Giuseppe Borzacchiello; Orlando Paciello; Valentina Iovane; Leonardo Leonardi; Paola Maiolino; Brunella Restucci; Serenella Papparella; Sante Roperto
Journal:  Biomed Res Int       Date:  2013-06-05       Impact factor: 3.411

10.  The biology of papillomavirus latency.

Authors:  Gareth Adam Maglennon; John Doorbar
Journal:  Open Virol J       Date:  2012-12-28
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