Literature DB >> 14573692

Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection.

Stanley M Spinola1, Cliffton T H Bong, Andrew L Faber, Kate R Fortney, Stacy L Bennett, Carisa A Townsend, Beth E Zwickl, Steven D Billings, Tricia L Humphreys, Margaret E Bauer, Barry P Katz.   

Abstract

With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.

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Year:  2003        PMID： 14573692      PMCID： PMC219599          DOI： 10.1128/IAI.71.11.6658-6663.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  50 in total

1.  Haemophilus ducreyi associates with phagocytes, collagen, and fibrin and remains extracellular throughout infection of human volunteers.

Authors:  M E Bauer; M P Goheen; C A Townsend; S M Spinola
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

Review 2.  Lyme disease.

Authors:  A C Steere
Journal:  N Engl J Med       Date:  2001-07-12       Impact factor: 91.245

3.  The ethical challenge of infection-inducing challenge experiments.

Authors:  F G Miller; C Grady
Journal:  Clin Infect Dis       Date:  2001-09-05       Impact factor: 9.079

4.  Haemophilus ducreyi inhibits phagocytosis by U-937 cells, a human macrophage-like cell line.

Authors:  G E Wood; S M Dutro; P A Totten
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

5.  Characterization of Haemophilus ducreyi-specific T-cell lines from lesions of experimentally infected human subjects.

Authors:  V Gelfanova; T L Humphreys; S M Spinola
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

6.  Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars.

Authors:  F B Niessen; M P Andriessen; J Schalkwijk; L Visser; W Timens
Journal:  J Pathol       Date:  2001-06       Impact factor: 7.996

Review 7.  Type 1/Type 2 immunity in infectious diseases.

Authors:  B Spellberg; J E Edwards
Journal:  Clin Infect Dis       Date:  2000-12-15       Impact factor: 9.079

8.  Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway.

Authors:  A O Tzianabos; A Chandraker; W Kalka-Moll; F Stingele; V M Dong; R W Finberg; R Peach; M H Sayegh
Journal:  Infect Immun       Date:  2000-12       Impact factor: 3.441

9.  Haemophilus ducreyi lipooligosaccharide mutant defective in expression of beta-1,4-glucosyltransferase is virulent in humans.

Authors:  R S Young; M J Filiatrault; K R Fortney; A F Hood; B P Katz; R S Munson; A A Campagnari; S M Spinola
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

10.  DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers.

Authors:  C T Bong; R E Throm; K R Fortney; B P Katz; A F Hood; C Elkins; S M Spinola
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441
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  24 in total

1.  Sialylation of lipooligosaccharides is dispensable for the virulence of Haemophilus ducreyi in humans.

Authors:  Stanley M Spinola; Wei Li; Kate R Fortney; Diane M Janowicz; Beth Zwickl; Barry P Katz; Robert S Munson
Journal:  Infect Immun       Date:  2011-12-05       Impact factor: 3.441

2.  Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication.

Authors:  Diane M Janowicz; Klara Tenner-Racz; Paul Racz; Tricia L Humphreys; Carol Schnizlein-Bick; Kate R Fortney; Beth Zwickl; Barry P Katz; James J Campbell; David D Ho; Stanley M Spinola
Journal:  J Infect Dis       Date:  2007-04-05       Impact factor: 5.226

3.  Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers.

Authors:  Wei Li; Klara Tenner-Racz; Paul Racz; Diane M Janowicz; Kate R Fortney; Barry P Katz; Stanley M Spinola
Journal:  J Infect Dis       Date:  2010-06-15       Impact factor: 5.226

4.  Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells.

Authors:  Wei Li; Barry P Katz; Stanley M Spinola
Journal:  Infect Immun       Date:  2011-05-16       Impact factor: 3.441

5.  Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans.

Authors:  Kristy L B Mount; Carisa A Townsend; Sherri D Rinker; Xiaoping Gu; Kate R Fortney; Beth W Zwickl; Diane M Janowicz; Stanley M Spinola; Barry P Katz; Margaret E Bauer
Journal:  Infect Immun       Date:  2010-01-19       Impact factor: 3.441

6.  Expression of the LspA1 and LspA2 proteins by Haemophilus ducreyi is required for virulence in human volunteers.

Authors:  Diane M Janowicz; Kate R Fortney; Barry P Katz; Jo L Latimer; Kaiping Deng; Eric J Hansen; Stanley M Spinola
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

7.  Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers.

Authors:  Tricia L Humphreys; Lang Li; Xiaoman Li; Diane M Janowicz; Kate R Fortney; Qianqian Zhao; Wei Li; Jeanette McClintick; Barry P Katz; David S Wilkes; Howard J Edenberg; Stanley M Spinola
Journal:  Infect Immun       Date:  2007-09-24       Impact factor: 3.441

8.  Mechanism of human natural killer cell activation by Haemophilus ducreyi.

Authors:  Wei Li; Diane M Janowicz; Kate R Fortney; Barry P Katz; Stanley M Spinola
Journal:  J Infect Dis       Date:  2009-08-15       Impact factor: 5.226

9.  Haemophilus ducreyi partially activates human myeloid dendritic cells.

Authors:  Keith E Banks; Tricia L Humphreys; Wei Li; Barry P Katz; David S Wilkes; Stanley M Spinola
Journal:  Infect Immun       Date:  2007-10-08       Impact factor: 3.441

10.  Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers.

Authors:  Martin Singer; Wei Li; Servaas A Morré; Sander Ouburg; Stanley M Spinola
Journal:  J Infect Dis       Date:  2016-04-27       Impact factor: 5.226
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